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The effect of bivalirudin on costs and outcomes of treatment of ST-segment elevation myocardial infarction
by
Kroch, Eugene
, Hlatky, Mark A.
, Kessler, Daniel P.
in
Acute coronary syndromes
/ Angioplasty, Balloon, Coronary - adverse effects
/ Angioplasty, Balloon, Coronary - economics
/ Angioplasty, Balloon, Coronary - methods
/ Anticoagulants
/ Antithrombins - therapeutic use
/ Biological and medical sciences
/ Cardiology. Vascular system
/ Cardiovascular
/ Confidence intervals
/ Coronary heart disease
/ Coronary vessels
/ Disease
/ Drug therapy
/ Electrocardiography
/ Family medical history
/ Female
/ Follow-Up Studies
/ Health Care Costs - trends
/ Heart
/ Heart attacks
/ Heart surgery
/ Hirudins
/ Hospital costs
/ Humans
/ Hypotheses
/ Incidence
/ Length of Stay - trends
/ Male
/ Medical sciences
/ Middle Aged
/ Mortality
/ Myocardial Infarction - economics
/ Myocardial Infarction - therapy
/ Myocarditis. Cardiomyopathies
/ Patients
/ Peptide Fragments - therapeutic use
/ Postoperative Hemorrhage - economics
/ Postoperative Hemorrhage - epidemiology
/ Postoperative Hemorrhage - prevention & control
/ Recombinant Proteins - therapeutic use
/ Retrospective Studies
/ Treatment Outcome
2011
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The effect of bivalirudin on costs and outcomes of treatment of ST-segment elevation myocardial infarction
by
Kroch, Eugene
, Hlatky, Mark A.
, Kessler, Daniel P.
in
Acute coronary syndromes
/ Angioplasty, Balloon, Coronary - adverse effects
/ Angioplasty, Balloon, Coronary - economics
/ Angioplasty, Balloon, Coronary - methods
/ Anticoagulants
/ Antithrombins - therapeutic use
/ Biological and medical sciences
/ Cardiology. Vascular system
/ Cardiovascular
/ Confidence intervals
/ Coronary heart disease
/ Coronary vessels
/ Disease
/ Drug therapy
/ Electrocardiography
/ Family medical history
/ Female
/ Follow-Up Studies
/ Health Care Costs - trends
/ Heart
/ Heart attacks
/ Heart surgery
/ Hirudins
/ Hospital costs
/ Humans
/ Hypotheses
/ Incidence
/ Length of Stay - trends
/ Male
/ Medical sciences
/ Middle Aged
/ Mortality
/ Myocardial Infarction - economics
/ Myocardial Infarction - therapy
/ Myocarditis. Cardiomyopathies
/ Patients
/ Peptide Fragments - therapeutic use
/ Postoperative Hemorrhage - economics
/ Postoperative Hemorrhage - epidemiology
/ Postoperative Hemorrhage - prevention & control
/ Recombinant Proteins - therapeutic use
/ Retrospective Studies
/ Treatment Outcome
2011
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The effect of bivalirudin on costs and outcomes of treatment of ST-segment elevation myocardial infarction
by
Kroch, Eugene
, Hlatky, Mark A.
, Kessler, Daniel P.
in
Acute coronary syndromes
/ Angioplasty, Balloon, Coronary - adverse effects
/ Angioplasty, Balloon, Coronary - economics
/ Angioplasty, Balloon, Coronary - methods
/ Anticoagulants
/ Antithrombins - therapeutic use
/ Biological and medical sciences
/ Cardiology. Vascular system
/ Cardiovascular
/ Confidence intervals
/ Coronary heart disease
/ Coronary vessels
/ Disease
/ Drug therapy
/ Electrocardiography
/ Family medical history
/ Female
/ Follow-Up Studies
/ Health Care Costs - trends
/ Heart
/ Heart attacks
/ Heart surgery
/ Hirudins
/ Hospital costs
/ Humans
/ Hypotheses
/ Incidence
/ Length of Stay - trends
/ Male
/ Medical sciences
/ Middle Aged
/ Mortality
/ Myocardial Infarction - economics
/ Myocardial Infarction - therapy
/ Myocarditis. Cardiomyopathies
/ Patients
/ Peptide Fragments - therapeutic use
/ Postoperative Hemorrhage - economics
/ Postoperative Hemorrhage - epidemiology
/ Postoperative Hemorrhage - prevention & control
/ Recombinant Proteins - therapeutic use
/ Retrospective Studies
/ Treatment Outcome
2011
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The effect of bivalirudin on costs and outcomes of treatment of ST-segment elevation myocardial infarction
Journal Article
The effect of bivalirudin on costs and outcomes of treatment of ST-segment elevation myocardial infarction
2011
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Overview
Bivalirudin is commonly used during percutaneous coronary intervention (PCI) rather than unfractionated heparin. The higher cost of bivalirudin may be offset if it reduces costly bleeding complications and/or length of stay. We sought to assess the effect of using bivalirudin on the costs of care among patients with ST-segment elevation myocardial infarction (STEMI) undergoing PCI.
We analyzed data from 64,872 patients treated in 1 of 278 hospitals. The effect of overall hospital use of bivalirudin on clinical and economic outcomes was assessed using multivariable regression, based on average hospital use of treatments.
The use of bivalirudin among patients with STEMI treated with PCI varied widely across hospitals, with a median of 6.9% (interquartile range 2.3%-18.6%). After controlling for patient and hospital characteristics, use of bivalirudin rather than heparin and a glycoprotein IIb/IIIa inhibitor reduced bleeding (odds ratio 0.47,
P < .001), length of stay (−0.47 days,
P < .03), and hospital costs (−14%,
P < .04).
Use of bivalirudin among patients with STEMI treated with PCI appears to reduce bleeding and overall costs.
Publisher
Mosby, Inc,Mosby,Elsevier Limited
Subject
/ Angioplasty, Balloon, Coronary - adverse effects
/ Angioplasty, Balloon, Coronary - economics
/ Angioplasty, Balloon, Coronary - methods
/ Antithrombins - therapeutic use
/ Biological and medical sciences
/ Disease
/ Female
/ Heart
/ Hirudins
/ Humans
/ Male
/ Myocardial Infarction - economics
/ Myocardial Infarction - therapy
/ Myocarditis. Cardiomyopathies
/ Patients
/ Peptide Fragments - therapeutic use
/ Postoperative Hemorrhage - economics
/ Postoperative Hemorrhage - epidemiology
/ Postoperative Hemorrhage - prevention & control
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