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Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents

by Walter, Emmanuel B , Brandon, Donald M , Lockhart, Stephen , Koury, Kenneth , Absalon, Judith , Senders, Shelly , Frenck, Robert W , Bailey, Ruth , Mather, Susan , Thomas, Stephen J , Jansen, Kathrin U , Gruber, William C , Gurtman, Alejandra , Jennings, Timothy , Klein, Nicola P , Ma, Hua , Swanson, Kena A , Türeci, Özlem , Perez, John L , Xu, Xia , Kitchin, Nicholas , Kalina, Warren V , Tresnan, Dina B , Şahin, Uğur , Cooper, David , Dormitzer, Philip R

in Adolescence / Adolescent Medicine / Adolescents / Adverse events / Age / Confidence intervals / Coronavirus / Coronaviruses / COVID-19 / COVID-19 vaccines / Diaries / Disease transmission / Hepatitis / Herd immunity / Illnesses / Immune response / Immunization / Immunogenicity / Infections / Infectious Disease / Original / Pandemics / Pediatrics / Placebos / Population / Safety / Severe acute respiratory syndrome coronavirus 2 / Statistical analysis / Teenagers / Testing laboratories / Vaccine efficacy / Vaccines / Young adults

2021

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Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents

2021

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Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents

2021

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Journal Article

Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents

Walter, Emmanuel B,

Brandon, Donald M,

Lockhart, Stephen,

Koury, Kenneth,

Absalon, Judith,

Senders, Shelly,

Frenck, Robert W,

Bailey, Ruth,

Mather, Susan,

Thomas, Stephen J,

Jansen, Kathrin U,

Gruber, William C,

Gurtman, Alejandra,

Jennings, Timothy,

Klein, Nicola P,

Ma, Hua,

Swanson, Kena A,

Türeci, Özlem,

Perez, John L,

Xu, Xia,

Kitchin, Nicholas,

Kalina, Warren V,

Tresnan, Dina B,

Şahin, Uğur,

Cooper, David,

Dormitzer, Philip R

2021

Overview

This randomized trial of the BNT162b2 vaccine involved 2260 adolescents 12 to 15 years of age. Similar levels of antibody to SARS-CoV-2 were elicited in the 12-to-15-year-old participants and in 16-to-25-year-old participants in a parallel trial. Among participants with no evidence of previous infection, no cases of Covid-19 were diagnosed in vaccine recipients, as compared with 16 cases in placebo recipients.

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Publisher

Massachusetts Medical Society

Subject

Adolescence

/ Adolescent Medicine

/ Adolescents

/ Adverse events

/ Age

/ Confidence intervals

/ Coronavirus