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Phase 2b Trial of Interferon-free Therapy for Hepatitis C Virus Genotype 1
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Phase 2b Trial of Interferon-free Therapy for Hepatitis C Virus Genotype 1
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Journal Article
Phase 2b Trial of Interferon-free Therapy for Hepatitis C Virus Genotype 1
2014
Overview
In this phase 2 study, peginterferon-free regimens were effective in patients with hepatitis C virus genotype 1 infection.
Chronic hepatitis C virus (HCV) infection is a leading cause of cirrhosis, liver cancer, and end-stage liver disease.
1
The current standard of care for chronic HCV genotype 1 infection is pegylated interferon (peginterferon) and ribavirin, with a protease inhibitor (boceprevir or telaprevir).
2
Although the addition of a protease inhibitor has been associated with a significant increase in response rates, only approximately one third of patients who had not had a response to prior therapy with peginterferon and ribavirin had a sustained virologic response when re-treated with the addition of a protease inhibitor.
3
,
4
Furthermore, these therapies are associated with adverse . . .
Publisher
Massachusetts Medical Society
Subject
/ Adult
/ Aged
/ Antiviral Agents - adverse effects
/ Antiviral Agents - therapeutic use
/ Biological and medical sciences
/ Carbamates - adverse effects
/ Carbamates - therapeutic use
/ Fatigue
/ Female
/ Genotype
/ Headache
/ Hepacivirus - isolation & purification
/ Hepatitis C, Chronic - drug therapy
/ Humans
/ Macrocyclic Compounds - adverse effects
/ Macrocyclic Compounds - therapeutic use
/ Male
/ Nausea
/ Patients
/ Proline - analogs & derivatives
/ Protease Inhibitors - therapeutic use
/ Valine
