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Palatal donor site management using tissue adhesives with adjunctive coconut oil in a randomized clinical trial
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Palatal donor site management using tissue adhesives with adjunctive coconut oil in a randomized clinical trial
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Journal Article
Palatal donor site management using tissue adhesives with adjunctive coconut oil in a randomized clinical trial
2025
Overview
Management of the complications occurring in the donor area after epithelialized gingival graft (EGG) harvesting still poses a challenge for clinicians. This study aimed to evaluate the influence of gelatin sponge (GS), cyanoacrylate (CY), and coconut oil (CO) combination in comparison with GS + CY in donor site management. Fifty EGG were harvested from the lateral palate in 50 patients, who were subsequently randomized to receive the GS + CY (control) or GS + CY + CO combination (test). Postoperative pain perception (PP), quantity of analgesics (QA), epithelization level (EL), color match (CM), sensation loss (SL), postoperative discomfort (PD), and delayed bleeding (DB) were evaluated. The GS + CY + CO group showed lower PP scores compared to the GS + CY (
p
< 0.05). The QA intake was similar in both groups. On day 14, the GS + CY + CO group achieved 80% full EL rate, which was higher than the GS + CY group (32%) (
p
= 0.002). CM scores were higher in the GS + CY + CO group at all follow-up periods (
p
< 0.001). Both groups reported similar SL, PD, and DB values (
p
> 0.05). GS + CY + CO combination is more effective in reducing pain compared to GS + CO in donor site management after EGG harvesting. Additionally, GS + CY + CO combination may accelerate epithelialization and improve color match compared to GS + CY alone.
Clinical Trial Registration: ClinicalTrials.gov: NCT06583226.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Adult
/ Coconut Oil - administration & dosage
/ Coconut Oil - therapeutic use
/ Female
/ Humanities and Social Sciences
/ Humans
/ Male
/ Pain
/ Pain, Postoperative - prevention & control
/ Palate
/ Patients
/ Science
/ Surgery
/ Sutures
/ Tissue Adhesives - administration & dosage
