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Effect of Anti-IgE Therapy in Patients with Peanut Allergy
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Effect of Anti-IgE Therapy in Patients with Peanut Allergy
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Journal Article
Effect of Anti-IgE Therapy in Patients with Peanut Allergy
2003
Overview
Injections of TNX-901 may provide protection after ingestion of peanut.
Peanut allergy is characterized by symptoms and signs after ingestion that may include nausea, vomiting, diarrhea, abdominal pain, urticaria, angioedema, bronchospasm, hypotension, loss of consciousness, and death.
1
,
2
Although data from animals demonstrate that allergic reactions are mediated by antigen-specific IgE bound to high-affinity receptors for IgE (FcεRIs) on mast cells and basophils,
3
,
4
non-IgE pathways for anaphylaxis exist, at least in mice,
5
,
6
and direct clinical evidence of IgE involvement in peanut allergy in humans is lacking.
Approximately 1.5 million people in the United States have peanut allergy,
7
,
8
50 to 100 of whom die each year from unintended . . .
Publisher
Massachusetts Medical Society
Subject
/ Adult
/ Antibodies, Monoclonal - administration & dosage
/ Antibodies, Monoclonal - adverse effects
/ Antibodies, Monoclonal - therapeutic use
/ Antibodies, Monoclonal, Humanized
/ Biological and medical sciences
/ Female
/ Humans
/ Immunoglobulin E - immunology
/ Immunoglobulin G - immunology
/ Male
/ Peanut Hypersensitivity - drug therapy
