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Inhaled GM-CSF for Pulmonary Alveolar Proteinosis

by Ishii, Haruyuki , Sugiyama, Haruhito , Yamaguchi, Etsuro , Konno, Satoshi , Inoue, Yoshikazu , Ueda, Takahiro , Abe, Mitsuhiro , Tode, Naoki , Eda, Ryosuke , Arai, Toru , Nakata, Koh , Kitamura, Nobutaka , Izumi, Shinyu , Mikami, Ayako , Kondoh, Shotaro , Morimoto, Konosuke , Handa, Tomohiro , Oda, Miku , Tazawa, Ryushi , Tanaka, Takahiro , Takada, Toshinori , Hirai, Toyohiro , Takahashi, Ayumu , Nakagawa, Atsushi , Sakagami, Takuro , Hashimoto, Atsushi , Tatsumi, Koichiro , Ohkouchi, Shinya , Tomii, Keisuke , Asakawa, Katsuaki , Suzuki, Masaru , Tanaka, Takeshi

in Administration, Inhalation / Adult / Aged / Alveoli / Autoantibodies / Autoantibodies - blood / Autoimmune Diseases - diagnostic imaging / Autoimmune Diseases - drug therapy / Blood pressure / Chronic obstructive pulmonary disease / Clinical trials / Colony-stimulating factor / Computed tomography / Double-Blind Method / Drug Administration Schedule / Dyspnea / Female / Granulocyte-macrophage colony-stimulating factor / Granulocyte-Macrophage Colony-Stimulating Factor - administration & dosage / Granulocyte-Macrophage Colony-Stimulating Factor - adverse effects / Granulocyte-Macrophage Colony-Stimulating Factor - immunology / Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use / Humans / Immunologic Factors - administration & dosage / Immunologic Factors - adverse effects / Immunologic Factors - therapeutic use / Laboratories / Lung - diagnostic imaging / Lung - pathology / Male / Medical research / Middle Aged / Oxygen - blood / Oxygen tension / Patients / Proteins / Pulmonary Alveolar Proteinosis - diagnostic imaging / Pulmonary Alveolar Proteinosis - drug therapy / Pulmonary Alveolar Proteinosis - immunology / Pulmonary Diffusing Capacity / R&D / Recombinant Proteins - administration & dosage / Recombinant Proteins - adverse effects / Recombinant Proteins - therapeutic use / Research & development / Smoking - adverse effects / Surfactants / Tomography, X-Ray Computed / Walk Test

2019

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2019

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2019

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Journal Article

Inhaled GM-CSF for Pulmonary Alveolar Proteinosis

Ishii, Haruyuki,

Sugiyama, Haruhito,

Yamaguchi, Etsuro,

Konno, Satoshi,

Inoue, Yoshikazu,

Ueda, Takahiro,

Abe, Mitsuhiro,

Tode, Naoki,

Eda, Ryosuke,

Arai, Toru,

Nakata, Koh,

Kitamura, Nobutaka,

Izumi, Shinyu,

Mikami, Ayako,

Kondoh, Shotaro,

Morimoto, Konosuke,

Handa, Tomohiro,

Oda, Miku,

Tazawa, Ryushi,

Tanaka, Takahiro,

Takada, Toshinori,

Hirai, Toyohiro,

Takahashi, Ayumu,

Nakagawa, Atsushi,

Sakagami, Takuro,

Hashimoto, Atsushi,

Tatsumi, Koichiro,

Ohkouchi, Shinya,

Tomii, Keisuke,

Asakawa, Katsuaki,

Suzuki, Masaru,

Tanaka, Takeshi

2019

Overview

In patients with autoimmune pulmonary alveolar proteinosis, the use of inhaled recombinant granulocyte–macrophage colony-stimulating factor resulted in a significantly better alveolar–arterial oxygen gradient at 25 weeks than the use of placebo. The beneficial effect was not observed in smokers.

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Publisher

Massachusetts Medical Society

Subject

Administration, Inhalation

/ Adult

/ Aged

/ Alveoli

/ Autoantibodies

/ Autoantibodies - blood

/ Autoimmune Diseases - diagnostic imaging