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Neutralization of the SARS-CoV-2 Omicron BA.4/5 and BA.2.12.1 Subvariants

by Evans, John P. , Liu, Shan-Lu , Mallampalli, Rama K. , Lozanski, Gerard , Carlin, Claire , Qu, Panke , Gumina, Richard J. , Faraone, Julia , Zou, Xue , Bednash, Joseph S. , Saif, Linda J. , Mohler, Peter J. , Oltz, Eugene M. , Zheng, Yi-Min

in Antibodies / Antibodies, Neutralizing / Coronavirus / Coronaviruses / Correspondence / COVID-19 / COVID-19 - diagnosis / COVID-19 - immunology / COVID-19 - virology / COVID-19 vaccines / Health care / Hospitalization / Humans / Infectious Disease / Intensive care / Medical personnel / mRNA / Mutation / Neutralization Tests / Pandemics / SARS-CoV-2 - immunology / Severe acute respiratory syndrome coronavirus 2 / Spike Glycoprotein, Coronavirus - immunology / Vaccination / Vaccines / Viral Infections

2022

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Neutralization of the SARS-CoV-2 Omicron BA.4/5 and BA.2.12.1 Subvariants

2022

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Neutralization of the SARS-CoV-2 Omicron BA.4/5 and BA.2.12.1 Subvariants

2022

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Journal Article

Neutralization of the SARS-CoV-2 Omicron BA.4/5 and BA.2.12.1 Subvariants

Evans, John P.,

Liu, Shan-Lu,

Mallampalli, Rama K.,

Lozanski, Gerard,

Carlin, Claire,

Qu, Panke,

Gumina, Richard J.,

Faraone, Julia,

Zou, Xue,

Bednash, Joseph S.,

Saif, Linda J.,

Mohler, Peter J.,

Oltz, Eugene M.,

Zheng, Yi-Min

2022

Overview

After two doses of mRNA vaccine, health care workers had less viral neutralizing-antibody activity against the BA.4/5 and BA.2.12.1 omicron subvariants than against the BA.1 and BA.2 subvariants, but titers increased significantly with a booster dose.

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Publisher

Massachusetts Medical Society

Subject

Antibodies

/ Antibodies, Neutralizing

/ COVID-19 - diagnosis