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PDX1: A unique pancreatic master regulator constantly changes its functions during embryonic development and progression of pancreatic cancer
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PDX1: A unique pancreatic master regulator constantly changes its functions during embryonic development and progression of pancreatic cancer
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Journal Article
PDX1: A unique pancreatic master regulator constantly changes its functions during embryonic development and progression of pancreatic cancer
2017
Overview
Multifunctional activity of the
PDX1
gene product is reviewed. The PDX1 protein is unique in that being expressed exclusively in the pancreas it exhibits various functional activities in this organ both during embryonic development and during induction and progression of pancreatic cancer. Hence, PDX1 belongs to the family of master regulators with multiple and often antagonistic functions.
Publisher
Pleiades Publishing,Springer,Springer Nature B.V
Subject
/ Biomedical and Life Sciences
/ Cancer
/ Carcinoma, Pancreatic Ductal - metabolism
/ Carcinoma, Pancreatic Ductal - pathology
/ Homeodomain Proteins - metabolism
/ Humans
/ Pancreas
/ Pancreas - growth & development
/ Pancreatic Neoplasms - metabolism
/ Pancreatic Neoplasms - pathology
/ Trans-Activators - metabolism
/ Transcription Factors - genetics
