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Safety and Efficacy of a Third Dose of BNT162b2 Covid-19 Vaccine

by Nell, Haylene , Lu, Claire , Berhe, Mezgebe , Dormitzer, Philip R. , Jennings, Timothy W. , Moreira, Edson D. , Dever, Michael E. , Lockhart, Stephen , Koury, Kenneth , Hammitt, Laura L. , Koren, Michael J. , Zerbini, Cristiano , Cannon, Kevin D. , Swanson, Kena A. , Tresnan, Dina B. , Denham, Douglas S. , Brandon, Donald M. , Klein, Nicola P. , Wang, Xingbin , Gurtman, Alejandra , Keep, Georgina , Lagkadinou, Eleni , Fitz-Patrick, David , Jansen, Kathrin U. , Dychter, Samuel S. , Perez, John L. , Türeci, Özlem , Xu, Xia , Kitchin, Nicholas , Gruber, William C. , Şahin, Uğur , Cooper, David

in Age / BNT162 Vaccine / Clinical trials / Confidence intervals / Coronavirus / Coronaviruses / COVID-19 - prevention & control / COVID-19 vaccines / COVID-19 Vaccines - adverse effects / Health care / Heart diseases / Humans / Immunization / Infections / Infectious Disease / Informed consent / Laboratories / Myocarditis / Original / Pandemics / Pericarditis / Placebos / Safety / SARS-CoV-2 / Severe acute respiratory syndrome coronavirus 2 / Surveillance / Vaccine efficacy / Vaccines / Viral Infections

2022

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Safety and Efficacy of a Third Dose of BNT162b2 Covid-19 Vaccine

2022

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2022

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Journal Article

Safety and Efficacy of a Third Dose of BNT162b2 Covid-19 Vaccine

Nell, Haylene,

Lu, Claire,

Berhe, Mezgebe,

Dormitzer, Philip R.,

Jennings, Timothy W.,

Moreira, Edson D.,

Dever, Michael E.,

Lockhart, Stephen,

Koury, Kenneth,

Hammitt, Laura L.,

Koren, Michael J.,

Zerbini, Cristiano,

Cannon, Kevin D.,

Swanson, Kena A.,

Tresnan, Dina B.,

Denham, Douglas S.,

Brandon, Donald M.,

Klein, Nicola P.,

Wang, Xingbin,

Gurtman, Alejandra,

Keep, Georgina,

Lagkadinou, Eleni,

Fitz-Patrick, David,

Jansen, Kathrin U.,

Dychter, Samuel S.,

Perez, John L.,

Türeci, Özlem,

Xu, Xia,

Kitchin, Nicholas,

Gruber, William C.,

Şahin, Uğur,

Cooper, David

2022

Overview

In an extension of the pivotal randomized trial showing vaccine efficacy, approximately 10,000 adults who had received two doses of BNT162b2 were assigned to receive a third dose or placebo. Local reactions were common but mild and transient. During a median follow-up of 2.5 months, SARS-CoV-2 was identified in 6 participants in the vaccine group and in 123 in the placebo group, for a vaccine efficacy of 95.3%.

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Publisher

Massachusetts Medical Society

Subject

Age

/ BNT162 Vaccine

/ Clinical trials

/ Confidence intervals

/ Coronavirus

/ Coronaviruses

/ COVID-19 - prevention & control