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Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets
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Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets
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Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets
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Journal Article
Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets
2022
Overview
While the seroprevalence of SARS-CoV-2 in healthy people does not differ significantly among age groups, those aged 65 years or older exhibit strikingly higher COVID-19 mortality compared to younger individuals. To further understand differing COVID-19 manifestations in patients of different ages, three age groups of ferrets are infected with SARS-CoV-2. Although SARS-CoV-2 is isolated from all ferrets regardless of age, aged ferrets (≥3 years old) show higher viral loads, longer nasal virus shedding, and more severe lung inflammatory cell infiltration, and clinical symptoms compared to juvenile (≤6 months) and young adult (1–2 years) groups. Furthermore, direct contact ferrets co-housed with the virus-infected aged group shed more virus than direct-contact ferrets co-housed with virus-infected juvenile or young adult ferrets. Transcriptome analysis of aged ferret lungs reveals strong enrichment of gene sets related to type I interferon, activated T cells, and M1 macrophage responses, mimicking the gene expression profile of severe COVID-19 patients. Thus, SARS-CoV-2-infected aged ferrets highly recapitulate COVID-19 patients with severe symptoms and are useful for understanding age-associated infection, transmission, and pathogenesis of SARS-CoV-2.
Here, Kim et al. characterize SARS-CoV-2 infection in juvenile, young, and old aged ferrets to provide a further understanding of differences in COVID-19 severity in humans at different ages. Aged ferrets have higher viral loads, shed virus longer, and mimic the transcriptomic profile of severely infected patients.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38
/ 38/39
/ 38/91
/ Age
/ Animals
/ Antibodies, Neutralizing - blood
/ Antibodies, Neutralizing - immunology
/ Antibodies, Viral - immunology
/ COVID-19
/ Female
/ Ferrets
/ Gene Expression Profiling - methods
/ Humanities and Social Sciences
/ Humans
/ Immunoglobulin G - immunology
/ Lungs
/ Mimicry
/ Mustela
/ Patients
/ Science
/ Serology
/ Severe acute respiratory syndrome coronavirus 2
/ Viruses
