Asset Details
Do you wish to reserve the book?
Nuclear genome of Bulinus truncatus, an intermediate host of the carcinogenic human blood fluke Schistosoma haematobium
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Nuclear genome of Bulinus truncatus, an intermediate host of the carcinogenic human blood fluke Schistosoma haematobium
Do you wish to request the book?
Nuclear genome of Bulinus truncatus, an intermediate host of the carcinogenic human blood fluke Schistosoma haematobium
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Nuclear genome of Bulinus truncatus, an intermediate host of the carcinogenic human blood fluke Schistosoma haematobium
2022
Overview
Some snails act as intermediate hosts (vectors) for parasitic flatworms (flukes) that cause neglected tropical diseases, such as schistosomiases.
Schistosoma haematobium
is a blood fluke that causes urogenital schistosomiasis and induces bladder cancer and increased risk of HIV infection. Understanding the molecular biology of the snail and its relationship with the parasite could guide development of an intervention approach that interrupts transmission. Here, we define the genome for a key intermediate host of
S. haematobium
—called
Bulinus truncatus
—and explore protein groups inferred to play an integral role in the snail’s biology and its relationship with the schistosome parasite.
Bu. truncatus
shared many orthologous protein groups with
Biomphalaria glabrata
—the key snail vector for
S. mansoni
which causes hepatointestinal schistosomiasis in people. Conspicuous were expansions in signalling and membrane trafficking proteins, peptidases and their inhibitors as well as gene families linked to immune response regulation, such as a large repertoire of lectin-like molecules. This work provides a sound basis for further studies of snail-parasite interactions in the search for targets to block schistosomiasis transmission.
The snail
Bulinus truncatus
is an intermediate host of the carcinogenic human blood fluke
Schistosoma haematobium
. Here the authors report the genome of
Bu. truncatus
, explore protein groups inferred to play a role in its interaction with the schistosome parasite, and identify expansions in gene families linked to immune response regulation.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/23
/ 45
/ 45/91
/ 631/601
/ Animals
/ Biology
/ Blood
/ Genome
/ Genomes
/ HIV
/ Host-Parasite Interactions - genetics
/ Host-Parasite Interactions - immunology
/ Human immunodeficiency virus
/ Humanities and Social Sciences
/ Humans
/ Proteins
/ Schistosoma haematobium - immunology
/ Schistosomiasis haematobia - parasitology
/ Schistosomiasis haematobia - transmission
/ Science
/ Snails
/ Vectors
