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Hippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory
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Hippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory
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Journal Article
Hippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory
2018
Overview
The hippocampus is essential for representing spatiotemporal context and establishing its association with the sensory details of daily life to form episodic memories. The olfactory cortex in particular shares exclusive anatomical connections with the hippocampus as a result of their common evolutionary history. Here we selectively inhibit hippocampal projections to the anterior olfactory nucleus (AON) during behavioural tests of contextually cued odour recall. We find that spatial odour memory and temporal odour memory are independently impaired following inhibition of distinct, topographically organized hippocampal-AON pathways. Our results not only reveal a longstanding unknown function for the AON but offer new mechanistic insights regarding the representation of odours in episodic memory.
Hippocampus is necessary for integrating the context with sensory cues to retrieve memory for unique episodes. Here, the authors show that inhibiting topographically organized projections from hippocampus to the anterior olfactory nucleus independently impairs spatial and temporal odour memory recall.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/63
/ 64/60
/ Animals
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Clozapine - analogs & derivatives
/ Cues
/ Hippocampus - anatomy & histology
/ Humanities and Social Sciences
/ Luminescent Proteins - genetics
/ Luminescent Proteins - metabolism
/ Male
/ Memory
/ Mice
/ Nuclei
/ Odors
/ Olfactory Bulb - anatomy & histology
/ Olfactory Bulb - drug effects
/ Olfactory Cortex - anatomy & histology
/ Olfactory Cortex - drug effects
/ Olfactory Cortex - physiology
/ Olfactory Pathways - anatomy & histology
/ Olfactory Pathways - drug effects
/ Olfactory Pathways - physiology
/ Recall
/ Science
/ Space Perception - physiology
