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Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility
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Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility
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Journal Article
Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility
2021
Overview
Tissue turnover requires activation and lineage commitment of tissue-resident stem cells (SCs). These processes are impacted by ageing, but the mechanisms remain unclear. Here, we addressed the mechanisms of ageing in murine hair follicle SCs (HFSCs) and observed a widespread reduction in chromatin accessibility in aged HFSCs, particularly at key self-renewal and differentiation genes, characterized by bivalent promoters occupied by active and repressive chromatin marks. Consistent with this, aged HFSCs showed reduced ability to activate bivalent genes for efficient self-renewal and differentiation. These defects were niche dependent as the transplantation of aged HFSCs into young recipients or synthetic niches restored SC functions. Mechanistically, the aged HFSC niche displayed widespread alterations in extracellular matrix composition and mechanics, resulting in mechanical stress and concomitant transcriptional repression to silence promoters. As a consequence, increasing basement membrane stiffness recapitulated age-related SC changes. These data identify niche mechanics as a central regulator of chromatin state, which, when altered, leads to age-dependent SC exhaustion.
Koester et al. show that, as hair follicle stem cells age, their ability to activate bivalent genes for self-renewal and differentiation is reduced due to increased niche stiffening and subsequent epigenetic effects.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/31
/ 14
/ 14/19
/ 14/28
/ 14/3
/ 45
/ 45/100
/ 45/15
/ 45/91
/ 631/532
/ 631/80
/ Age
/ Aging
/ Animals
/ Biomedical and Life Sciences
/ Cell Differentiation - genetics
/ Cell Self Renewal - genetics
/ Cellular Senescence - genetics
/ Chromatin Assembly and Disassembly
/ Extracellular Matrix - physiology
/ Genes
/ Hair
/ Male
/ Mechanotransduction, Cellular
/ Mice
