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One-Unit versus Two-Unit Cord-Blood Transplantation for Hematologic Cancers
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One-Unit versus Two-Unit Cord-Blood Transplantation for Hematologic Cancers
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Journal Article
One-Unit versus Two-Unit Cord-Blood Transplantation for Hematologic Cancers
2014
Overview
The use of two units of cord blood to reconstitute hematopoiesis in transplantation for relapsed hematologic cancers in patients 1 to 21 years of age proved to be no better and was in some ways worse than the standard one-unit transplant.
Since 1993, unrelated-donor umbilical-cord blood has been used as the source of hematopoietic stem cells for transplantation in an estimated 30,000 patients with malignant and nonmalignant diseases.
1
As compared with stem-cell grafts from adult donors, cord blood has the advantages of more rapid availability, relative absence of donor attrition, and, after transplantation, a reduced risk of graft-versus-host disease (GVHD) despite donor–recipient HLA disparity.
2
,
3
In addition, less restriction on HLA matching permits greater use of cord blood for members of racial minorities, who are less likely to have a suitably HLA-matched volunteer adult donor.
4
However, the use of cord blood . . .
Publisher
Massachusetts Medical Society
Subject
/ Biological and medical sciences
/ Blood
/ Cancer
/ Child
/ Children
/ Cord Blood Stem Cell Transplantation - adverse effects
/ Cord Blood Stem Cell Transplantation - methods
/ Cord Blood Stem Cell Transplantation - mortality
/ Female
/ Graft vs Host Disease - epidemiology
/ Graft vs Host Disease - prevention & control
/ Hematologic Neoplasms - mortality
/ Hematologic Neoplasms - therapy
/ Histocompatibility antigen HLA
/ Humans
/ Infant
/ Male
/ Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
/ Patients
/ Transplantation Conditioning
/ Tumors
