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Thrombospondin Type-1 Domain-Containing 7A in Idiopathic Membranous Nephropathy

by Meyer-Schwesinger, Catherine , Debayle, Delphine , Merchant, Michael , Stahl, Rolf A.K , Helmchen, Udo , Zahner, Gunther , Seitz-Polski, Barbara , Beck, Laurence H , Dabert-Gay, Anne-Sophie , Klein, Jon , Salant, David J , Tomas, Nicola M , Ma, Hong , Dolla, Guillaume , Hoxha, Elion , Lambeau, Gérard

in Antigens / Autoantibodies / Autoantibodies - blood / Autoimmune diseases / Biological and medical sciences / Biopsy / Blotting, Western / Case-Control Studies / General aspects / Glomerulonephritis / Glomerulonephritis, Membranous - blood / Glomerulonephritis, Membranous - immunology / Glycosylation / Humans / Immunoglobulin G / Immunoprecipitation / Kidney Glomerulus - metabolism / Localization / Lysates / Mass spectroscopy / Medical sciences / Membranous nephropathy / Nephrology. Urinary tract diseases / Nephropathies. Renovascular diseases. Renal failure / Nephropathy / Phospholipase A2 / Receptors, Phospholipase A2 - blood / Receptors, Phospholipase A2 - immunology / Receptors, Phospholipase A2 - metabolism / Thrombospondin / Thrombospondins - blood / Thrombospondins - immunology / Thrombospondins - metabolism / Western blotting

2014

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Thrombospondin Type-1 Domain-Containing 7A in Idiopathic Membranous Nephropathy

2014

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2014

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Journal Article

Thrombospondin Type-1 Domain-Containing 7A in Idiopathic Membranous Nephropathy

Meyer-Schwesinger, Catherine,

Debayle, Delphine,

Merchant, Michael,

Stahl, Rolf A.K,

Helmchen, Udo,

Zahner, Gunther,

Seitz-Polski, Barbara,

Beck, Laurence H,

Dabert-Gay, Anne-Sophie,

Klein, Jon,

Salant, David J,

Tomas, Nicola M,

Ma, Hong,

Dolla, Guillaume,

Hoxha, Elion,

Lambeau, Gérard

2014

Overview

Idiopathic membranous nephropathy is associated with autoantibodies against the phospholipase A2 receptor (PLA2R1) in about 70% of patients. This study identifies another antigen, thrombospondin type-1 domain-containing 7A (THSD7A), which accounts for about 10% of cases. Idiopathic membranous nephropathy is an autoimmune disease and a common cause of the nephrotic syndrome in adults. 1 In 2009, the phospholipase A2 receptor 1 (PLA2R1), a protein that is expressed in glomerular podocytes, was discovered as the major antigen involved in the pathogenesis of adult idiopathic membranous nephropathy. 2 As confirmed by a number of subsequent studies, about 70% of patients with idiopathic membranous nephropathy have circulating autoantibodies against PLA2R1. 2 – 6 The remaining patients, approximately 30% of those with idiopathic membranous nephropathy, have no obvious secondary cause of the disease, and it is thought that other endogenous glomerular antigens may be . . .

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Publisher

Massachusetts Medical Society

Subject

Antigens

/ Autoantibodies

/ Autoantibodies - blood

/ Autoimmune diseases

/ Biological and medical sciences

/ Biopsy

/ Blotting, Western