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HOX gene expression in the developing human spine

by Li, Tong , Anderson, Nathaniel D. , Balogh, Petra , Mazin, Pavel , Young, Matthew D. , Prigmore, Elena , Roberts, Kenny , Flanagan, Adrienne , Piapi, Alice , He, Xiaoling , Mamanova, Lira , Teichmann, Sarah A. , Tuck, Elizabeth , Barker, Roger A. , Bayraktar, Omer , Usher, Inga , Behjati, Sam , Bolt, Liam , Lawrence, John E. G. , Richardson, Laura

in 13 / 14/32 / 38/39 / 38/62 / 38/91 / 631/136/1660/1993 / 631/136/368/2430 / 631/378/2597/2600 / Collinearity / Embryos / Fetuses / Gene expression / Gene Expression Profiling / Gene Expression Regulation, Developmental / Gene sequencing / Genes / Genes, Homeobox - genetics / Homeodomain Proteins - genetics / Homeodomain Proteins - metabolism / HOX gene / Humanities and Social Sciences / Humans / multidisciplinary / Pattern formation / Science / Science (multidisciplinary) / Single-Cell Analysis / Source code / Spinal cord / Spinal Cord - embryology / Spinal Cord - metabolism / Spine - embryology / Spine - metabolism / Transcriptome / Transcriptomics

2024

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2024

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2024

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Journal Article

HOX gene expression in the developing human spine

Li, Tong,

Anderson, Nathaniel D.,

Balogh, Petra,

Mazin, Pavel,

Young, Matthew D.,

Prigmore, Elena,

Roberts, Kenny,

Flanagan, Adrienne,

Piapi, Alice,

He, Xiaoling,

Mamanova, Lira,

Teichmann, Sarah A.,

Tuck, Elizabeth,

Barker, Roger A.,

Bayraktar, Omer,

Usher, Inga,

Behjati, Sam,

Bolt, Liam,

Lawrence, John E. G.,

Richardson, Laura

2024

Overview

Positional coding along the anterior-posterior axis is regulated by HOX genes, whose 3’ to 5’ expression correlates with location along this axis. The precise utilisation of HOX genes in different human cell types is not fully understood. Here, we use single-cell and spatial-transcriptomics, along with in-situ sequencing, to create a developmental atlas of the human fetal spine. We analyse HOX gene expression across cell types during development, finding that neural-crest derivatives unexpectedly retain the anatomical HOX code of their origin while also adopting the code of their destination. This trend is confirmed across multiple organs. In the axial plane of the spinal cord, we find distinct patterns in the ventral and dorsal domains, providing insights into motor pool organisation and loss of collinearity in HOXB genes. Our findings shed new light on HOX gene expression in the developing spine, highlighting a HOX gene ‘source code’ in neural-crest cell derivatives. The HOX gene cluster is responsible for anteroposterior axis patterning in an evolutionarily conserved manner. Here they examine HOX gene expression in human embryos and show that neural-crest derivatives retain the anatomical HOX code of their origin while also adopting the code of their destination.

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Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

/ 14/32

/ 38/39

/ 38/62

/ 38/91

/ 631/136/1660/1993

/ 631/136/368/2430

/ 631/378/2597/2600