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Zirconium-catalyzed one-pot synthesis of benzoxazoles using reaction of catechols, aldehydes and ammonium acetate
by
Sasanipour, Maryam
, Sharghi, Hashem
, Aboonajmi, Jasem
, Mohammadi, Masoumeh
, Panahi, Farhad
in
639/638
/ 704/172
/ Acetic acid
/ Acids
/ Aldehydes
/ Ammonium
/ Ammonium acetate
/ Cosmetics
/ Ethanol
/ Humanities and Social Sciences
/ Investigations
/ Methods
/ multidisciplinary
/ Natural products
/ Oxidants
/ Oxidizing agents
/ Science
/ Science (multidisciplinary)
/ Solvents
/ Zirconium
/ β-Lactam antibiotics
2024
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Zirconium-catalyzed one-pot synthesis of benzoxazoles using reaction of catechols, aldehydes and ammonium acetate
by
Sasanipour, Maryam
, Sharghi, Hashem
, Aboonajmi, Jasem
, Mohammadi, Masoumeh
, Panahi, Farhad
in
639/638
/ 704/172
/ Acetic acid
/ Acids
/ Aldehydes
/ Ammonium
/ Ammonium acetate
/ Cosmetics
/ Ethanol
/ Humanities and Social Sciences
/ Investigations
/ Methods
/ multidisciplinary
/ Natural products
/ Oxidants
/ Oxidizing agents
/ Science
/ Science (multidisciplinary)
/ Solvents
/ Zirconium
/ β-Lactam antibiotics
2024
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Zirconium-catalyzed one-pot synthesis of benzoxazoles using reaction of catechols, aldehydes and ammonium acetate
by
Sasanipour, Maryam
, Sharghi, Hashem
, Aboonajmi, Jasem
, Mohammadi, Masoumeh
, Panahi, Farhad
in
639/638
/ 704/172
/ Acetic acid
/ Acids
/ Aldehydes
/ Ammonium
/ Ammonium acetate
/ Cosmetics
/ Ethanol
/ Humanities and Social Sciences
/ Investigations
/ Methods
/ multidisciplinary
/ Natural products
/ Oxidants
/ Oxidizing agents
/ Science
/ Science (multidisciplinary)
/ Solvents
/ Zirconium
/ β-Lactam antibiotics
2024
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Zirconium-catalyzed one-pot synthesis of benzoxazoles using reaction of catechols, aldehydes and ammonium acetate
Journal Article
Zirconium-catalyzed one-pot synthesis of benzoxazoles using reaction of catechols, aldehydes and ammonium acetate
2024
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Overview
In this study, an efficient method for the synthesis of benzoxazoles by coupling catechols, aldehydes and ammonium acetate using ZrCl
4
as catalyst in ethanol is reported. A wide range of benzoxazoles (59 examples) are smoothly produced in high yields (up to 97%). Other advantages of the method include large-scale synthesis and the use of oxygen as an oxidant. The mild reaction conditions allowed late-stage functionalization, facilitating access to several derivatives with biologically relevant structures such as
β
-lactam and quinoline heterocycles.
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