Asset Details
Do you wish to reserve the book?
Molecular mechanisms of ferroptosis and its role in cancer therapy
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Molecular mechanisms of ferroptosis and its role in cancer therapy
Do you wish to request the book?
Molecular mechanisms of ferroptosis and its role in cancer therapy
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Molecular mechanisms of ferroptosis and its role in cancer therapy
2019
Overview
Ferroptosis is a newly defined programmed cell death process with the hallmark of the accumulation of iron‐dependent lipid peroxides. The term was first coined in 2012 by the Stockwell Lab, who described a unique type of cell death induced by the small molecules erastin or RSL3. Ferroptosis is distinct from other already established programmed cell death and has unique morphological and bioenergetic features. The physiological role of ferroptosis during development has not been well characterized. However, ferroptosis shows great potentials during the cancer therapy. Great progress has been made in exploring the mechanisms of ferroptosis. In this review, we focus on the molecular mechanisms of ferroptosis, the small molecules functioning in ferroptosis initiation and ferroptosis sensitivity in different cancers. We are also concerned with the new arising questions in this particular research area that remains unanswered.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc
Subject
Antineoplastic Agents - pharmacology
/ Antineoplastic Agents - therapeutic use
/ Endoplasmic Reticulum Stress - drug effects
/ Endoplasmic Reticulum Stress - genetics
/ Enzymes
/ Fatty Acids, Unsaturated - metabolism
/ Humans
/ Lipids
/ Mutation
/ Phospholipid Hydroperoxide Glutathione Peroxidase - antagonists & inhibitors
/ Phospholipid Hydroperoxide Glutathione Peroxidase - metabolism
/ Reagents
/ Review
/ Reviews
/ Signal Transduction - drug effects
