Journal Article

Therapeutic Hypothermia after Out-of-Hospital Cardiac Arrest in Children

Slomine, Beth S, Wheeler, Derek S, Theodorou, Andreas A, Shah, Samir, Bennett, Kimberly S, Sanders, Ronald C, Dean, J. Michael, Zimmerman, Jerry J, Lidsky, Karen, Thomas, Neal J, Wu, Theodore, Ofori-Amanfo, George, van der Jagt, Elise W, Nowak, Jeffrey E, Schwarz, Adam J, Clark, Amy E, Lloyd, Eric, Pineda, Jose A, Nadkarni, Vinay M, Meert, Kathleen L, Berger, John T, Holubkov, Richard, Porter, Melissa B, Meyer, Michael T, Silverstein, Faye S, McQuillen, Patrick, Pham, Nga, Topjian, Alexis, Browning, Brittan, Bhalala, Utpal S, Page, Kent, Newth, Christopher J.L, Goodman, Denise M, Moler, Frank W, Dalton, Heidi J, Koch, Joshua D, Harrison, Rick, Shankaran, Seetha, Schleien, Charles L, Mathur, Mudit, Pemberton, Victoria L, Fink, Ericka L, Hutchison, Jamie S, Christensen, James R, Alten, Jeffrey

2015

Overview

This study of targeted temperature interventions in 295 children who were comatose after cardiac arrest showed no significant difference between the hypothermia group (33.0°C) and the normothermia group (36.8°C) with respect to 1-year survival with a good functional outcome. Out-of-hospital cardiac arrest in children often results in death or in poor long-term functional outcome in survivors. 1 – 3 In 2002, two trials involving adults showed that therapeutic hypothermia improved neurologic outcomes in comatose survivors after out-of-hospital cardiac arrest with ventricular fibrillation or ventricular tachycardia. 4 , 5 International guidelines recommend therapeutic hypothermia for adults with out-of-hospital cardiac arrest who have similar characteristics. 6 , 7 Recently, another trial involving adults after out-of-hospital cardiac arrest showed that therapeutic hypothermia with the use of a target temperature of 33°C, as compared with actively maintained therapeutic normothermia (36°C), did not improve outcomes. 8 The fundamental difference between this . . .

• Publisher: Massachusetts Medical Society
• Subject: Adolescent / Cardiac arrest / Cardiac arrhythmia / Cardiopulmonary resuscitation / Child / Child, Preschool / Children / Children & youth / Coma / CPR / Female / Heart / Heart attacks / Humans / Hypothermia / Hypothermia, Induced - adverse effects / Infant / Male / Mortality / Out-of-Hospital Cardiac Arrest - complications / Out-of-Hospital Cardiac Arrest - mortality / Out-of-Hospital Cardiac Arrest - therapy / Survival / Temperature effects / Treatment Outcome / Unconsciousness - etiology / Unconsciousness - therapy