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Emergence and global spread of a dominant multidrug-resistant clade within Acinetobacter baumannii
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Emergence and global spread of a dominant multidrug-resistant clade within Acinetobacter baumannii
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Journal Article
Emergence and global spread of a dominant multidrug-resistant clade within Acinetobacter baumannii
2025
Overview
The proliferation of multi-drug resistant (MDR) bacteria is driven by the global spread of epidemic lineages that accumulate antimicrobial resistance genes (ARGs).
Acinetobacter baumannii
, a leading cause of nosocomial infections, displays resistance to most frontline antimicrobials and represents a significant challenge to public health. In this study, we conduct a comprehensive genomic analysis of over 15,000
A. baumannii
genomes to identify a predominant epidemic super-lineage (ESL) accounting for approximately 70% of global isolates. Through hierarchical classification of the ESL into distinct lineages, clusters, and clades, we identified a stepwise evolutionary trajectory responsible for the worldwide expansion and transmission of
A. baumannii
over the last eight decades. We observed the rise and global spread of a previously unrecognized Clade 2.5.6, which emerged in East Asia in 2006. The epidemic of the clade is linked to the ongoing acquisition of ARGs and virulence factors facilitated by genetic recombination. Our results highlight the necessity for One Health-oriented research and interventions to address the spread of this MDR pathogen.
In this study, authors conduct a genomic analysis of 15,000 Acinetobacter baumannii isolates, revealing a dominant multidrug-resistant super-lineage (accounting for approximately 70% global isolates), with Clade 2.5.6 emerging in East Asia in 2006.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Acinetobacter baumannii - classification
/ Acinetobacter baumannii - drug effects
/ Acinetobacter baumannii - genetics
/ Acinetobacter baumannii - isolation & purification
/ Acinetobacter baumannii - pathogenicity
/ Acinetobacter Infections - epidemiology
/ Acinetobacter Infections - microbiology
/ Acinetobacter Infections - transmission
/ Anti-Bacterial Agents - pharmacology
/ Cross Infection - epidemiology
/ Cross Infection - microbiology
/ Drug Resistance, Multiple, Bacterial - genetics
/ Genomes
/ Humanities and Social Sciences
/ Humans
/ Science
