Journal Article

Outcomes of post-operative drain use after cranioplasty surgery – a systematic review and meta-analysis

Mee, Harry, Cook, William H., Lisitsyna, Alexandra, Ashraf, Mohammad, Kingham, Matthew, Helmy, Adel, Lee, Keng Siang, Li, Zhikai, Timofeev, Ivan, Chedid, Youssef, Al-Munaer, Marwan, Hutchinson, Peter J., Guo, Yuhan, Veremu, Munashe, Gillespie, Conor S., Karepov, Yevgeny, Yang, Shangqing W.

2026

Overview

Background Cranioplasty restores cranial integrity following decompressive craniectomy or skull trauma. Despite its reconstructive benefits, post-cranioplasty complication rates are high. Post-operative drainage has been proposed to mitigate these risks, yet its effectiveness remains uncertain. This study evaluates the impact of post-cranioplasty drain insertion on surgical outcomes. Methods A systematic literature search of MEDLINE, Embase, and Cochrane CENTRAL Library was conducted in accordance with PRISMA guidelines (PROSPEROID:CRD420251030365). Studies reporting cranioplasty outcomes with post-operative drainage were selected. Primary outcomes were complication rates, including infection, haemorrhage, and cerebrospinal fluid (CSF) leak. Results Four studies met the inclusion criteria, comprising 522 patients (mean age 43.7 years) who underwent cranioplasty—282 with post-operative drainage and 240 without. Following decompressive craniectomy, the most common indications for cranioplasty were traumatic brain injury (196/514, 38.1%), vascular causes (187/514, 36.4%), and infection (25/514, 4.9%). All studies reported subgaleal drain use, with one study (25%) using epidural drains in an unspecified number of patients. The overall post-operative complication rate was 75/522 (14.4%), occurring in 23/282 drained patients (8.2%) and 52/240 (21.7%) undrained patients. A meta-analysis comparing post-operative complication rates across all studies between patients with and without post-cranioplasty drainage yielded a pooled risk ratio (RR) of 0.51 (95% CI: 0.21–1.24, p  = 0.095). Conclusions The results suggest post-cranioplasty drainage does not significantly alter complication rates. However, heterogeneity in drainage protocols limits attribution of outcomes to specific modalities. Going forward, moderated prospective trials are needed to establish standardised post-cranioplasty drainage protocols.

• Publisher: Springer Vienna,Springer Nature B.V,Springer
• Subject: Brain Injuries, Traumatic - surgery / Cerebrospinal fluid / Clinical trials / Cohort analysis / Complications / Cranioplasty / Decompressive Craniectomy - adverse effects / Drainage - methods / Edema / Epidural / Epidural drain / Hemorrhage / Humans / Infections / Interventional Radiology / Medicine / Medicine & Public Health / Meta-analysis / Minimally Invasive Surgery / Neurology / Neuroradiology / Neurosurgery / Plastic Surgery Procedures / Post-operative complications / Postoperative / Postoperative Care - methods / Postoperative Complications / Skull / Skull - surgery / Subgaleal drain / Surgical drains / Surgical Orthopedics / Surgical outcomes / Systematic review / Traumatic brain injury / Treatment Outcome / Tumors / Wound drainage