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A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics

by Ali, Rosine , Mukadi, Daniel , Coulibaly, Sinaré , Lusakibanza Manzo, Mariano , Ibanda, Augustin , Lane, H. Clifford , Proschan, Michael , Mulangu, Sabue , Nzolo, Didier , Tshomba Oloma, Antoine , Levine, Adam C , Muyembe-Tamfum, Jean-Jacques , the PALM Writing Group , Grais, Rebecca , Davey, Richard T , Diaz, Janet , Dodd, Lori E , Tshiani Mbaya, Olivier

in Adenosine Monophosphate - analogs & derivatives / Adolescent / Adult / Alanine - adverse effects / Alanine - analogs & derivatives / Alanine - therapeutic use / Allergies / Antibodies, Monoclonal - adverse effects / Antibodies, Monoclonal - therapeutic use / Antiviral agents / Antiviral Agents - adverse effects / Antiviral Agents - therapeutic use / Antiviral drugs / Child / Child, Preschool / Consortia / Creatinine / Democratic Republic of the Congo - epidemiology / Disease Outbreaks / DNA-directed RNA polymerase / Drug dosages / Ebola virus / Ebolavirus / Ebolavirus - genetics / Epidemics / Female / Hemorrhagic Fever, Ebola - drug therapy / Hemorrhagic Fever, Ebola - mortality / Humans / Infant / Infant, Newborn / Infectious diseases / Infusions, Intravenous / Intravenous administration / Male / Monoclonal antibodies / Mortality / Outbreaks / R&D / Research & development / Ribonucleic acid / Ribonucleotides - adverse effects / Ribonucleotides - therapeutic use / RNA / RNA polymerase / RNA viruses / RNA, Viral - blood / Single-Blind Method / Young Adult

2019

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A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics

2019

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2019

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Journal Article

A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics

Ali, Rosine,

Mukadi, Daniel,

Coulibaly, Sinaré,

Lusakibanza Manzo, Mariano,

Ibanda, Augustin,

Lane, H. Clifford,

Proschan, Michael,

Mulangu, Sabue,

Nzolo, Didier,

Tshomba Oloma, Antoine,

Levine, Adam C,

Muyembe-Tamfum, Jean-Jacques,

the PALM Writing Group,

Grais, Rebecca,

Davey, Richard T,

Diaz, Janet,

Dodd, Lori E,

Tshiani Mbaya, Olivier

2019

Overview

Ebola transmission has been ongoing in the Democratic Republic of Congo since August 2018. In this trial of MAb114, REGN-EB3, remdesivir, and ZMapp (as the control), mortality from Ebola virus disease was lower in the MAb114 and REGN-EB3 groups than in the other groups.

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Publisher

Massachusetts Medical Society

Subject

Adenosine Monophosphate - analogs & derivatives

/ Adolescent

/ Adult

/ Alanine - adverse effects

/ Alanine - analogs & derivatives

/ Alanine - therapeutic use

/ Allergies