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Comparative analysis of the bronchoalveolar microbiome in Portuguese patients with different chronic lung disorders
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Comparative analysis of the bronchoalveolar microbiome in Portuguese patients with different chronic lung disorders
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Journal Article
Comparative analysis of the bronchoalveolar microbiome in Portuguese patients with different chronic lung disorders
2021
Overview
The lung is inhabited by a diverse microbiome that originates from the oropharynx by a mechanism of micro-aspiration. Its bacterial biomass is usually low; however, this condition shifts in lung cancer (LC), chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD). These chronic lung disorders (CLD) may coexist in the same patient as comorbidities and share common risk factors, among which the microbiome is included. We characterized the microbiome of 106 bronchoalveolar lavages. Samples were initially subdivided into cancer and non-cancer and high-throughput sequenced for the 16S rRNA gene. Additionally, we used a cohort of 25 CLD patients where crossed comorbidities were excluded. Firmicutes, Proteobacteria and Bacteroidetes were the most prevalent phyla independently of the analyzed group.
Streptococcus
and
Prevotella
were associated with LC and
Haemophilus
was enhanced in COPD versus ILD. Although no significant discrepancies in microbial diversity were observed between cancer and non-cancer samples, statistical tests suggested a gradient across CLD where COPD and ILD displayed the highest and lowest alpha diversities, respectively. Moreover, COPD and ILD were separated in two clusters by the unweighted UniFrac distance (
P
value = 0.0068). Our results support the association of
Streptoccocus
and
Prevotella
with LC and of
Haemophilus
with COPD, and advocate for specific CLD signatures.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
