Journal Article

Diabetic Microvascular Disease: An Endocrine Society Scientific Statement

Khamaisi, Mogher, Barrett, Eugene J, King, George L, Bowden, Donald W, Casellini, Carolina M, Liu, Zhenqi, Hughes, Timothy M, Freedman, Barry I, Klein, Ronald, Vinik, Aaron I, Craft, Suzanne, Klein, Barbara E K

2017

Overview

Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs. Our understanding of the genesis of this injury and of potential interventions to prevent, limit, or reverse injury/dysfunction is continuously evolving. This statement reviews biochemical/cellular pathways involved in facilitating and abrogating microvascular injury. The statement summarizes the types of injury/dysfunction that occur in the three classical diabetes microvascular target tissues, the eye, the kidney, and the peripheral nervous system; the statement also reviews information on the effects of diabetes and insulin resistance on the microvasculature of skin, brain, adipose tissue, and cardiac and skeletal muscle. Despite extensive and intensive research, it is disappointing that microvascular complications of diabetes continue to compromise the quantity and quality of life for patients with diabetes. Hopefully, by understanding and building on current research findings, we will discover new approaches for prevention and treatment that will be effective for future generations.This scientific statement reviews and discusses the microvascular complications of diabetes on an organ-by-organ basis.

• Publisher: Endocrine Society,Copyright Oxford University Press,Oxford University Press
• Subject: Adipose tissue / Cardiac muscle / Diabetes / Diabetes mellitus / Diabetes mellitus (insulin dependent) / Diabetes mellitus (non-insulin dependent) / Heart diseases / Insulin / Insulin resistance / Microvasculature / Nervous system / Quality of life / Scientific Statement / Skeletal muscle / Skin