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Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a
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Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a
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Journal Article
Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a
2023
Overview
Gut microbiota plays a key role in insulin resistance (IR). Here we perform a case-control study of Chinese adults (ChiCTR2200065715) and identify that
Parabacteroides distasonis
is inversely correlated with IR. Treatment with
P. distasonis
improves IR, strengthens intestinal integrity, and reduces systemic inflammation in mice. We further demonstrate that
P. distasonis-
derived nicotinic acid (NA) is a vital bioactive molecule that fortifies intestinal barrier function via activating intestinal G-protein-coupled receptor 109a (GPR109a), leading to ameliorating IR. We also conduct a bioactive dietary fiber screening to induce
P. distasonis
growth.
Dendrobium officinale
polysaccharide (DOP) shows favorable growth-promoting effects on
P. distasonis
and protects against IR in mice simultaneously. Finally, the reduced
P. distasonis
and NA levels were also validated in another human type 2 diabetes mellitus cohort. These findings reveal the unique mechanisms of
P. distasonis
on IR and provide viable strategies for the treatment and prevention of IR by bioactive dietary fiber.
Here, the authors show that the gut commensal
Parabacteroides distasonis
alleviates insulin resistance via nicotinic acid-intestinal GPR109a axis activation, a process promoted by
Dendrobium officinale
polysaccharide.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/1
/ 13/51
/ 45/22
/ 45/77
/ 45/90
/ 45/91
/ 64/60
/ Animals
/ Diabetes mellitus (non-insulin dependent)
/ Diabetes Mellitus, Type 2 - drug therapy
/ Humanities and Social Sciences
/ Humans
/ Insulin
/ Mice
/ Science
