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A new perspective on lysogeny: prophages as active regulatory switches of bacteria
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A new perspective on lysogeny: prophages as active regulatory switches of bacteria
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Journal Article
A new perspective on lysogeny: prophages as active regulatory switches of bacteria
2015
Overview
In this Opinion article, Herskovits and colleagues introduce an emerging class of bacteria–phage symbiotic interaction — which they term 'active lysogeny' — in which phages regulate the expression of bacterial genes by precise insertion and excision events.
Unlike lytic phages, temperate phages that enter lysogeny maintain a long-term association with their bacterial host. In this context, mutually beneficial interactions can evolve that support efficient reproduction of both phages and bacteria. Temperate phages are integrated into the bacterial chromosome as large DNA insertions that can disrupt gene expression, and they may pose a fitness burden on the cell. However, they have also been shown to benefit their bacterial hosts by providing new functions in a bacterium–phage symbiotic interaction termed lysogenic conversion. In this Opinion article, we discuss another type of bacterium–phage interaction, active lysogeny, in which phages or phage-like elements are integrated into the bacterial chromosome within critical genes or operons and serve as switches that regulate bacterial genes via genome excision.
Publisher
Nature Publishing Group UK,Nature Publishing Group
