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Alpha Emitter Radium-223 and Survival in Metastatic Prostate Cancer

by Bottomley, D , Garcia-Vargas, J , Nilsson, S , Heinrich, D , Solberg, A , O'Sullivan, J.M , Coleman, R , Helle, S.I , Dall'Oglio, M , Shan, M , Kliment, J , Staudacher, K , James, N.D , Seke, M , Johannessen, D.C , Chodacki, A , Wedel, S , Sartor, O , Hoskin, P , O'Bryan-Tear, C.G , Boehmer, S , Bruland, Ø.S , Parker, C , Logue, J , Fosså, S.D , Widmark, A , Franzén, L , Wiechno, P , Syndikus, I , Vogelzang, N.J

in Aged / Aged, 80 and over / Biological and medical sciences / Body weight / Bone cancer / Bone Neoplasms - mortality / Bone Neoplasms - radiotherapy / Bone Neoplasms - secondary / Cancer therapies / Castration / Double-Blind Method / Double-blind studies / General aspects / Humans / Isotopes / Kaplan-Meier Estimate / Male / Medical sciences / Metastases / Middle Aged / Multiple tumors. Solid tumors. Tumors in childhood (general aspects) / Myelosuppression / Nephrology. Urinary tract diseases / Pain / Prostate cancer / Prostatic Neoplasms - mortality / Prostatic Neoplasms - pathology / Prostatic Neoplasms - radiotherapy / Radium / Radium - adverse effects / Radium - therapeutic use / Survival / Tumors / Tumors of the urinary system / Urinary tract. Prostate gland

2013

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Alpha Emitter Radium-223 and Survival in Metastatic Prostate Cancer

2013

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Alpha Emitter Radium-223 and Survival in Metastatic Prostate Cancer

2013

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Journal Article

Alpha Emitter Radium-223 and Survival in Metastatic Prostate Cancer

Bottomley, D,

Garcia-Vargas, J,

Nilsson, S,

Heinrich, D,

Solberg, A,

O'Sullivan, J.M,

Coleman, R,

Helle, S.I,

Dall'Oglio, M,

Shan, M,

Kliment, J,

Staudacher, K,

James, N.D,

Seke, M,

Johannessen, D.C,

Chodacki, A,

Wedel, S,

Sartor, O,

Hoskin, P,

O'Bryan-Tear, C.G,

Boehmer, S,

Bruland, Ø.S,

Parker, C,

Logue, J,

Fosså, S.D,

Widmark, A,

Franzén, L,

Wiechno, P,

Syndikus, I,

Vogelzang, N.J

2013

Overview

In a study involving men with castration-resistant prostate cancer and bone metastases, the alpha emitter radium-223 significantly prolonged survival, as compared with placebo, and was associated with fewer adverse events. More than 90% of patients with metastatic castration-resistant prostate cancer have radiologic evidence of bone metastases, which are a major cause of death, disability, decreased quality of life, and increased treatment cost among these patients. 1 , 2 Unlike deaths from many other types of cancer, deaths from prostate cancer are often due to bone disease and its complications. 3 Current bone-targeted therapies have not been shown to improve survival, and the benefits derived from bisphosphonates, denosumab, and existing radioisotope treatments are primarily limited to pain relief and delay of skeletal events. 4 – 13 Radium-223 dichloride (radium-223) is a targeted alpha emitter that selectively . . .

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Publisher

Massachusetts Medical Society

Subject

Aged

/ Aged, 80 and over

/ Biological and medical sciences

/ Body weight

/ Bone cancer

/ Bone Neoplasms - mortality

/ Bone Neoplasms - radiotherapy