Journal Article

Prospective associations between serum biomarkers of lipid metabolism and overall, breast and prostate cancer risk

Touvier, Mathilde, Kesse-Guyot, Emmanuelle, His, Mathilde, Zelek, Laurent, Deschasaux, Mélanie, Pouchieu, Camille, Galan, Pilar, Latino-Martel, Paule, Hercberg, Serge, Blacher, Jacques

2014

Overview

Experimental studies provided evidence about mechanisms by which cholesterol, especially high density lipoprotein cholesterol (HDL-C), could influence carcinogenesis, notably through antioxidant and anti-inflammatory properties. However, prospective studies that investigated the associations between specific lipid metabolism biomarkers and cancer risk provided inconsistent results. The objective was to investigate the prospective associations between total cholesterol (T-C), HDL-C, low density lipoprotein cholesterol, apolipoproteins A1 (apoA1) and B, and triglycerides and overall, breast and prostate cancer risk. Analyses were performed on 7,557 subjects of the Supplementation en Vitamines et Mineraux Antioxydants Study, a nationwide French cohort study. Biomarkers of lipid metabolism were measured at baseline and analyzed regarding the risk of first primary incident cancer (N = 514 cases diagnosed during follow-up, 1994-2007), using Cox proportional hazards models. T-C was inversely associated with overall (HR1(mmol/L increment) = 0.91, 95 % CI 0.82-1.00; P = 0.04) and breast (HR1mmol/L increment = 0.83, 95 % CI 0.69-0.99; P = 0.04) cancer risk. HDL-C was also inversely associated with overall (HR1mmol/L increment = 0.61, 95 % CI 0.46-0.82; P = 0.0008) and breast (HR1mmol/L increment = 0.48, 95 % CI 0.28-0.83; P = 0.009) cancer risk. Consistently, apoA1 was inversely associated with overall (HR1g/L increment = 0.56, 95 % CI 0.39-0.82; P = 0.003) and breast (HR1g/L increment = 0.36, 95 % CI 0.18-0.73; P = 0.004) cancer risk. This prospective study suggests that pre-diagnostic serum levels of T-C, HDL-C and ApoA1 are associated with decreased overall and breast cancer risk. The confirmation of a role of cholesterol components in cancer development, by further large prospective and experimental studies, may have important implications in terms of public health, since cholesterol is already crucial in cardiovascular prevention.

• Publisher: Springer Verlag,CCSD,Springer,Springer Netherlands,Springer Nature B.V
• Subject: Adult / Aged / Apolipoprotein A-I - blood / Apolipoproteins B - blood / Biological and medical sciences / Biological markers / Biomarkers / Biomarkers - blood / Breast cancer / Breast Neoplasms - blood / Breast Neoplasms - epidemiology / Cancer / Carcinogenesis / Cardiology / Cholesterol / Cholesterol, HDL - blood / Cholesterol, LDL - blood / Cholesterols / Epidemiology / Experimentation / Female / Follow-Up Studies / Food and Nutrition / General aspects / Gynecology. Andrology. Obstetrics / Health risks / Humans / Infectious Diseases / Life Sciences / Lipid Metabolism / Lipids / Lipids - blood / Lipoproteins / Male / Mammary gland diseases / Medical sciences / Medicine / Medicine & Public Health / Metabolism / Middle Aged / Miscellaneous / Nephrology. Urinary tract diseases / Oncology / Proportional Hazards Models / Prospective Studies / Prostate / Prostate cancer / Prostatic Neoplasms - blood / Prostatic Neoplasms - epidemiology / Public Health / Public health. Hygiene / Public health. Hygiene-occupational medicine / Risk Factors / Santé publique et épidémiologie / Triglycerides - blood / Tumors / Tumors of the urinary system / Urinary tract. Prostate gland
• ISBN: 0003352308000