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Recent Progress in Regulating the Activity of Enzymes with Photoswitchable Inhibitors
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Recent Progress in Regulating the Activity of Enzymes with Photoswitchable Inhibitors
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Journal Article
Recent Progress in Regulating the Activity of Enzymes with Photoswitchable Inhibitors
2024
Overview
Photoregulation of biomolecules has become crucial tools in chemical biology, because light enables access under mild conditions and with delicate spatiotemporal control. The control of enzyme activity in a reversible way is a challenge. To achieve it, a facile approach is to use photoswitchable inhibitors. This review highlights recent progress in photoswitchable inhibitors based on azobenzenes units. The progress suggests that the incorporation of an azobenzene unit to a known inhibitor is an effective method for preparing a photoswitchable inhibitor, and with these photoswitchable inhibitors, the activity of enzymes can be regulated by optical control, which is valuable in both basic science and therapeutic applications.
Publisher
MDPI AG,MDPI
Subject
