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Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients

by Guo, Mingquan , Wu, Qingguo , Cheng, Mengjun , Yang, Lan , Le, Shuai , Guo, Xiaokui , Li, Jianhui , Xing, Shunpeng , Cai, Jinfeng , Zhu, Mingli , Li, Tao , Li, Linlin , Zhu, Zhaoqin , Shi, Lei , Zhang, Jianzhong , Lu, Hongzhou , Yao, Bangxin , Gu, Jingmin , Li, Feng , Wu, Nannan , Zhou, Xin , Tan, Demeng , Zhang, Yiyuan , Zhu, Tongyu , Qu, Hongping , Gao, Yuan , Ling, Yun , Tan, Ruoming , Dai, Jia , Jin, Jing , Qin, Jinhong , Li, Jie , Song, Zhigang , Chen, Li-Kuang

in Acinetobacter baumannii - physiology / Acinetobacter baumannii - virology / Acinetobacter Infections - etiology / Acinetobacter Infections - microbiology / Acinetobacter Infections - therapy / Aged / Aged, 80 and over / Bacterial infections / Bacteriophages - physiology / carbapenem-resistant Acinetobacter baumannii / Coinfection - microbiology / Coinfection - therapy / Coronaviruses / COVID-19 / COVID-19 - complications / COVID-19 - virology / Female / Good Manufacturing Practice / Humans / Male / nosocomial infections / Phage Therapy / Podoviridae - physiology / SARS-CoV-2 - physiology / Silk

2021

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Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients

2021

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2021

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Journal Article

Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients

Guo, Mingquan,

Wu, Qingguo,

Cheng, Mengjun,

Yang, Lan,

Le, Shuai,

Guo, Xiaokui,

Li, Jianhui,

Xing, Shunpeng,

Cai, Jinfeng,

Zhu, Mingli,

Li, Tao,

Li, Linlin,

Zhu, Zhaoqin,

Shi, Lei,

Zhang, Jianzhong,

Lu, Hongzhou,

Yao, Bangxin,

Gu, Jingmin,

Li, Feng,

Wu, Nannan,

Zhou, Xin,

Tan, Demeng,

Zhang, Yiyuan,

Zhu, Tongyu,

Qu, Hongping,

Gao, Yuan,

Ling, Yun,

Tan, Ruoming,

Dai, Jia,

Jin, Jing,

Qin, Jinhong,

Li, Jie,

Song, Zhigang,

Chen, Li-Kuang

2021

Overview

Phage therapy is recognized as a promising alternative to antibiotics in treating pulmonary bacterial infections, however, its use has not been reported for treating secondary bacterial infections during virus pandemics such as coronavirus disease 2019 (COVID-19). We enrolled 4 patients hospitalized with critical COVID-19 and pulmonary carbapenem-resistant Acinetobacter baumannii (CRAB) infections to compassionate phage therapy (at 2 successive doses of 10 9 plaque-forming unit phages). All patients in our COVID-19-specific intensive care unit (ICU) with CRAB positive in bronchoalveolar lavage fluid or sputum samples were eligible for study inclusion if antibiotic treatment failed to eradicate their CRAB infections. While phage susceptibility testing revealed an identical profile of CRAB strains from these patients, treatment with a pre-optimized 2-phage cocktail was associated with reduced CRAB burdens. Our results suggest the potential of phages on rapid responses to secondary CRAB outbreak in COVID-19 patients.

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Publisher

Taylor & Francis,Taylor & Francis Ltd,Taylor & Francis Group

Subject

Acinetobacter baumannii - physiology

/ Acinetobacter baumannii - virology

/ Acinetobacter Infections - etiology

/ Acinetobacter Infections - microbiology

/ Acinetobacter Infections - therapy

/ Aged

/ Aged, 80 and over