Journal Article

Brief Report: Social Disability in Autism Spectrum Disorder: Results from Research Units on Pediatric Psychopharmacology (RUPP) Autism Network Trials

Vitiello, Benedetto, Eugene Arnold, L., Dziura, James, McDougle, Christopher J., Deng, Yanhong, McCracken, James T., Hallett, Victoria, Tierney, Elaine, Aman, Michael G., Scahill, Lawrence

2013

Overview

There is growing interest in measuring social disability as a core element of autism spectrum disorders in medication trials. We conducted a secondary analysis on the Aberrant Behavior Checklist Social Withdrawal subscale using data from two federally-funded, multi-site, randomized trials with risperidone. Study 1 included 52 subjects assigned to placebo and 49 subjects to risperidone under double-blind conditions. Study 2 included 49 subjects assigned to risperidone only and 75 subjects assigned to risperidone plus parent training. After 8 weeks of treatment, all active treatments were superior to placebo (effect sizes ranging from 0.42 to 0.65). The findings suggest that the Social Withdrawal subscale may be a useful measure of social disability in acute treatment trials.

• Publisher: Springer US,Springer,Springer Nature B.V
• Subject: Aberrant Behavior Checklist / Adolescent / Antipsychotic Agents - therapeutic use / Assignment / Autism / Autism Spectrum Disorders / Behavior Problems / Behavior Rating Scales / Behavioral Science and Psychology / Biological and medical sciences / Brief Report / Check Lists / Child / Child and School Psychology / Child clinical studies / Child Development Disorders, Pervasive - drug therapy / Child Development Disorders, Pervasive - psychology / Child, Preschool / Comparative Analysis / Developmental disorders / Disability / Disorders / Double-Blind Method / Drug Use / Drugs / Effect Size / Humans / Infantile autism / Measures / Medical sciences / Neuropharmacology / Neurosciences / Parent education / Parenthood education / Pediatrics / People with disabilities / Pervasive Developmental Disorders / Pharmacology / Pharmacology. Drug treatments / Placebo effect / Psychiatric Status Rating Scales / Psycholeptics: tranquillizer, neuroleptic / Psychology / Psychology. Psychoanalysis. Psychiatry / Psychopathology. Psychiatry / Psychopharmacology / Public Health / Research Design / Research units / Risperidone / Risperidone - therapeutic use / Social Behavior / Social Desirability / Social factors / Social networks / Social Perception / Treatment methods / Treatment Outcome / Withdrawal (Psychology)