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Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis

by Zhang, Hongyan , Szapary, Philippe , Sandborn, William J , Panaccione, Remo , Sands, Bruce E , O’Brien, Christopher D , Marano, Colleen , Abreu, Maria T , Targan, Stephan , Adedokun, Omoniyi J , Danese, Silvio , Hisamatsu, Tadakazu , Li, Katherine , Johanns, Jewel , Van Assche, Gert , Peyrin-Biroulet, Laurent

in Adult / Anti-Inflammatory Agents - administration & dosage / Anti-Inflammatory Agents - adverse effects / Anti-Inflammatory Agents - therapeutic use / Anti-Inflammatory Agents/administration & dosage/adverse effects/therapeutic use / Body weight / Cancer / Colitis, Ulcerative - drug therapy / Colon / Colorectal cancer / Crohn's disease / Cytokines / Dose-Response Relationship, Drug / Double-Blind Method / Endoscopy / Esophagus / Female / Gastroenterology / Gastroenterology & hepatology / Gastroentérologie & hépatologie / Hemorrhage / Human health sciences / Humans / Immunotherapy / Induction Chemotherapy / Induction therapy / Inflammatory bowel disease / Infusions, Intravenous / Injections, Subcutaneous / Interleukin 12 / Interleukin 23 / Intravenous administration / Life Sciences / Maintenance Chemotherapy / Male / Monoclonal antibodies / Patient Acuity / Prostate cancer / R&D / Rectum / Remission / Remission (Medicine) / Remission Induction - methods / Research & development / Respiratory distress syndrome / Sciences de la santé humaine / Skin cancer / Testicular cancer / Tumor necrosis factor-TNF / Ulcerative colitis / Ustekinumab - administration & dosage / Ustekinumab - adverse effects / Ustekinumab - therapeutic use / Ustekinumab/administration & dosage/adverse effects/therapeutic use

2019

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Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis

2019

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Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis

2019

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Journal Article

Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis

Zhang, Hongyan,

Szapary, Philippe,

Sandborn, William J,

Panaccione, Remo,

Sands, Bruce E,

O’Brien, Christopher D,

Marano, Colleen,

Abreu, Maria T,

Targan, Stephan,

Adedokun, Omoniyi J,

Danese, Silvio,

Hisamatsu, Tadakazu,

Li, Katherine,

Johanns, Jewel,

Van Assche, Gert,

Peyrin-Biroulet, Laurent

2019

Overview

Patients with moderate-to-severe ulcerative colitis were randomly assigned to receive placebo or induction doses of ustekinumab. Patients who had a response to induction therapy underwent a second randomization to maintenance therapy with ustekinumab or placebo. Ustekinumab was more effective than placebo for inducing and maintaining remission.

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Anti-Inflammatory Agents - administration & dosage

/ Anti-Inflammatory Agents - adverse effects

/ Anti-Inflammatory Agents - therapeutic use

/ Anti-Inflammatory Agents/administration & dosage/adverse effects/therapeutic use

/ Body weight

/ Cancer