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Tau deposition is associated with functional isolation of the hippocampus in aging
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Tau deposition is associated with functional isolation of the hippocampus in aging
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Journal Article
Tau deposition is associated with functional isolation of the hippocampus in aging
2019
Overview
The tau protein aggregates in aging and Alzheimer disease and may lead to memory loss through disruption of medial temporal lobe (MTL)-dependent memory systems. Here, we investigated tau-mediated mechanisms of hippocampal dysfunction that underlie the expression of episodic memory decline using fMRI measures of hippocampal local coherence (regional homogeneity; ReHo), distant functional connectivity and tau-PET. We show that age and tau pathology are related to higher hippocampal ReHo. Functional disconnection between the hippocampus and other components of the MTL memory system, particularly an anterior-temporal network specialized for object memory, is also associated with higher hippocampal ReHo and greater tau burden in anterior-temporal regions. These associations are not observed in the posteromedial network, specialized for context/spatial information. Higher hippocampal ReHo predicts worse memory performance. These findings suggest that tau pathology plays a role in disconnecting the hippocampus from specific MTL memory systems leading to increased local coherence and memory decline.
Deposition of tau protein aggregates occurs during aging and Alzheimer disease. Here, the authors show that tau burden in the anterior-temporal memory network is associated with disrupted fMRI connectivity and functional isolation of the hippocampus from other memory network components.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 59/57
/ 59/78
/ Adult
/ Age
/ Aged
/ Aging
/ Alzheimer Disease - diagnostic imaging
/ Alzheimer Disease - metabolism
/ Alzheimer Disease - physiopathology
/ Alzheimer Disease - psychology
/ Amyloid beta-Peptides - metabolism
/ Cognitive Aging - physiology
/ Cognitive Aging - psychology
/ Entorhinal Cortex - diagnostic imaging
/ Entorhinal Cortex - metabolism
/ Entorhinal Cortex - physiopathology
/ Female
/ Functional magnetic resonance imaging
/ Hippocampus - diagnostic imaging
/ Hippocampus - physiopathology
/ Humanities and Social Sciences
/ Humans
/ Male
/ Memory
/ Neural Pathways - diagnostic imaging
/ Neural Pathways - metabolism
/ Neural Pathways - physiopathology
/ Neurofibrillary Tangles - metabolism
/ Positron-Emission Tomography
/ Science
