Journal Article

Childhood Outcomes after Hypothermia for Neonatal Encephalopathy

Hintz, Susan R, Vaucher, Yvonne E, Green, Charles, Peralta-Carcelen, Myriam, Huitema, Carolyn M. Petrie, Gustafson, Kathryn E, Evans, Patricia W, Leach, Theresa M, Heyne, Roy J, Goldstein, Ricki F, Dusick, Anna M, Adams-Chapman, Ira, Guillet, Ronnie, Yolton, Kimberly, Higgins, Rosemary D, Hammond, Jane, Wilson-Costello, Deanne E, McDonald, Scott A, Vohr, Betty R, Tyson, Jon E, Bauer, Charles R, Bara, Rebecca, Shankaran, Seetha, Papile, Lu-Ann, Ehrenkranz, Richard A, Pappas, Athina, Das, Abhik

2012

Overview

A prior report on hypothermia for neonatal hypoxic–ischemic encephalopathy showed a reduced rate of death or disability at 18 to 22 months of age. In this report of outcomes at 6 to 7 years, rates of death or an IQ below 70 were nonsignificantly lower with hypothermia than with usual care. Moderate or severe neonatal hypoxic–ischemic encephalopathy is associated with a high incidence of death or motor and sensory disability in children. 1 – 5 Children with encephalopathy are at risk for cognitive deficits even in the absence of functional deficits. Survivors without disability have delayed entry into primary school and fine-motor dysfunction and behavioral abnormalities. Hypothermia to 33 to 34°C for 72 hours, when initiated within 6 hours after birth among infants of more than 35 weeks' gestational age with hypoxic–ischemic encephalopathy, has been shown to reduce the risk of death or disability and increase the rate of survival free of disability . . .

• Publisher: Massachusetts Medical Society
• Subject: Age / Asphyxia Neonatorum / Biological and medical sciences / Body temperature / Brain damage / Cerebral palsy / Cerebral Palsy - epidemiology / Cerebral Palsy - etiology / Child, Preschool / Childhood / Children / Children & youth / Childrens health / Cognitive ability / Death / Developmental Disabilities - epidemiology / Developmental Disabilities - etiology / Disability / Encephalopathy / Esophagus / Female / General aspects / Humans / Hypothermia / Hypothermia, Induced / Hypoxia / Hypoxia-Ischemia, Brain - complications / Hypoxia-Ischemia, Brain - mortality / Hypoxia-Ischemia, Brain - therapy / Infant, Newborn / Infants / Intellectual Disability - epidemiology / Intellectual Disability - etiology / Intelligence / Intelligence Tests / Ischemia / Male / Medical sciences / Mortality / Neonates / Newborn babies / Parents & parenting / Quantitative psychology / Walking