Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Schlafen 5 as a novel therapeutic target in pancreatic ductal adenocarcinoma

by Mati, William M. , Arslan, Ahmet D. , Fish, Eleanor N. , Yang, Guang-Yu , Lee-Chang, Catalina , Qiang, Wenan , Platanias, Leonidas C. , Perez, Ricardo E. , Saleiro, Diana , Lesniak, Maciej S. , Eckerdt, Frank , Sun, Leyu , Oku, Chidera V. , Verzella, Daniela , Fischietti, Mariafausta , Beauchamp, Elspeth M. , Blyth, Gavin T. , Kosciuczuk, Ewa M.

in 13 / 13/106 / 13/31 / 13/44 / 13/51 / 38 / 59 / 59/5 / 631/67/1504/1713 / 631/80 / 82/58 / Adenocarcinoma / Animals / Apoptosis / Binding proteins / Carcinoma, Pancreatic Ductal - drug therapy / Carcinoma, Pancreatic Ductal - genetics / Carcinoma, Pancreatic Ductal - metabolism / Carcinoma, Pancreatic Ductal - pathology / Cell Biology / Cell cycle / Cell Cycle Proteins - genetics / Cell Cycle Proteins - metabolism / Cell Line, Tumor / Cell Proliferation / Development and progression / Gene deletion / Gene Expression Regulation, Neoplastic / Genetic aspects / Health aspects / Human Genetics / Humans / Internal Medicine / Medicine / Medicine & Public Health / Mice / Molecular Targeted Therapy - methods / Oncology / Pancreatic cancer / Pancreatic Neoplasms - genetics / Pancreatic Neoplasms - metabolism / Pancreatic Neoplasms - pathology / S phase / Therapeutic targets / Transcription / Tumorigenesis

2021

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Schlafen 5 as a novel therapeutic target in pancreatic ductal adenocarcinoma

2021

Confirm

Do you wish to request the book?

Schlafen 5 as a novel therapeutic target in pancreatic ductal adenocarcinoma

2021

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Schlafen 5 as a novel therapeutic target in pancreatic ductal adenocarcinoma

Mati, William M.,

Arslan, Ahmet D.,

Fish, Eleanor N.,

Yang, Guang-Yu,

Lee-Chang, Catalina,

Qiang, Wenan,

Platanias, Leonidas C.,

Perez, Ricardo E.,

Saleiro, Diana,

Lesniak, Maciej S.,

Eckerdt, Frank,

Sun, Leyu,

Oku, Chidera V.,

Verzella, Daniela,

Fischietti, Mariafausta,

Beauchamp, Elspeth M.,

Blyth, Gavin T.,

Kosciuczuk, Ewa M.

2021

Overview

We provide evidence that a member of the human Schlafen (SLFN) family of proteins, SLFN5, is overexpressed in human pancreatic ductal adenocarcinoma (PDAC). Targeted deletion of SLFN5 results in decreased PDAC cell proliferation and suppresses PDAC tumorigenesis in in vivo PDAC models. Importantly, high expression levels of SLFN5 correlate with worse outcomes in PDAC patients, implicating SLFN5 in the pathophysiology of PDAC that leads to poor outcomes. Our studies establish novel regulatory effects of SLFN5 on cell cycle progression through binding/blocking of the transcriptional repressor E2F7, promoting transcription of key genes that stimulate S phase progression. Together, our studies suggest an essential role for SLFN5 in PDAC and support the potential for developing new therapeutic approaches for the treatment of pancreatic cancer through SLFN5 targeting.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

/ 13/106

/ 13/31

/ 13/44

/ 13/51

/ 38

/ 59

/ 59/5