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Iron bioavailability from bouillon fortified with a novel ferric phytate compound: a stable iron isotope study in healthy women (part II)
by
Zimmermann, Michael B.
, Zeder, Christophe
, Habeych, Edwin
, Rey, Brigitte
, Sabatier, Magalie
, Galaffu, Nicola
, Dold, Susanne
, Grathwohl, Dominik
, Merinat, Sylvie
, Tajeri Foman, Jasmin
, Moretti, Diego
, Jeroense, Frederike
in
692/699/1702/295
/ 692/700/2814
/ Absorption
/ Adult
/ Bioavailability
/ Caco-2 Cells
/ Cross-Over Studies
/ Female
/ Ferric Compounds - chemistry
/ Ferric Compounds - pharmacokinetics
/ Ferritins - blood
/ Flavorings
/ Food
/ Food matrix
/ Food, Fortified
/ Humanities and Social Sciences
/ Humans
/ Hydrolysis
/ Iron
/ Iron - pharmacokinetics
/ Iron deficiency
/ Iron Radioisotopes - pharmacokinetics
/ Isotope studies
/ multidisciplinary
/ Nutrient deficiency
/ Phytic acid
/ Phytic Acid - chemistry
/ Plant Proteins, Dietary - chemistry
/ Science
/ Science (multidisciplinary)
/ Single-Blind Method
/ Young Adult
/ Zea mays - chemistry
2020
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Iron bioavailability from bouillon fortified with a novel ferric phytate compound: a stable iron isotope study in healthy women (part II)
by
Zimmermann, Michael B.
, Zeder, Christophe
, Habeych, Edwin
, Rey, Brigitte
, Sabatier, Magalie
, Galaffu, Nicola
, Dold, Susanne
, Grathwohl, Dominik
, Merinat, Sylvie
, Tajeri Foman, Jasmin
, Moretti, Diego
, Jeroense, Frederike
in
692/699/1702/295
/ 692/700/2814
/ Absorption
/ Adult
/ Bioavailability
/ Caco-2 Cells
/ Cross-Over Studies
/ Female
/ Ferric Compounds - chemistry
/ Ferric Compounds - pharmacokinetics
/ Ferritins - blood
/ Flavorings
/ Food
/ Food matrix
/ Food, Fortified
/ Humanities and Social Sciences
/ Humans
/ Hydrolysis
/ Iron
/ Iron - pharmacokinetics
/ Iron deficiency
/ Iron Radioisotopes - pharmacokinetics
/ Isotope studies
/ multidisciplinary
/ Nutrient deficiency
/ Phytic acid
/ Phytic Acid - chemistry
/ Plant Proteins, Dietary - chemistry
/ Science
/ Science (multidisciplinary)
/ Single-Blind Method
/ Young Adult
/ Zea mays - chemistry
2020
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Iron bioavailability from bouillon fortified with a novel ferric phytate compound: a stable iron isotope study in healthy women (part II)
by
Zimmermann, Michael B.
, Zeder, Christophe
, Habeych, Edwin
, Rey, Brigitte
, Sabatier, Magalie
, Galaffu, Nicola
, Dold, Susanne
, Grathwohl, Dominik
, Merinat, Sylvie
, Tajeri Foman, Jasmin
, Moretti, Diego
, Jeroense, Frederike
in
692/699/1702/295
/ 692/700/2814
/ Absorption
/ Adult
/ Bioavailability
/ Caco-2 Cells
/ Cross-Over Studies
/ Female
/ Ferric Compounds - chemistry
/ Ferric Compounds - pharmacokinetics
/ Ferritins - blood
/ Flavorings
/ Food
/ Food matrix
/ Food, Fortified
/ Humanities and Social Sciences
/ Humans
/ Hydrolysis
/ Iron
/ Iron - pharmacokinetics
/ Iron deficiency
/ Iron Radioisotopes - pharmacokinetics
/ Isotope studies
/ multidisciplinary
/ Nutrient deficiency
/ Phytic acid
/ Phytic Acid - chemistry
/ Plant Proteins, Dietary - chemistry
/ Science
/ Science (multidisciplinary)
/ Single-Blind Method
/ Young Adult
/ Zea mays - chemistry
2020
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Iron bioavailability from bouillon fortified with a novel ferric phytate compound: a stable iron isotope study in healthy women (part II)
Journal Article
Iron bioavailability from bouillon fortified with a novel ferric phytate compound: a stable iron isotope study in healthy women (part II)
2020
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Overview
Bouillon cubes are widely consumed and when fortified with iron could contribute in preventing iron deficiency. We report the development (part I) and evaluation (current part II) of a novel ferric phytate compound to be used as iron fortificant in condiments such as bouillon. Ferric pyrophosphate (FePP), is the compound of choice due to its high stability in foods, but has a modest absorption in humans. Our objective was to assess iron bioavailability from a novel iron fortificant consisting of ferric iron complexed with phytic acid and hydrolyzed corn protein (Fe-PA-HCP), used in bouillon with and without an inhibitory food matrix. In a randomised single blind, cross-over study, we measured iron absorption in healthy adult women (n = 22).
In vitro
iron bioaccessibility was assessed using a Caco-2 cell model. Iron absorption from Fe-PA-HCP was 1.5% and 4.1% in bouillon with and without inhibitory matrix, respectively. Relative iron bioavailability to FeSO
4
was 2.4 times higher than from FePP in bouillon (17% vs 7%) and 5.2 times higher when consumed with the inhibitory meal (41% vs 8%). Similar results were found
in vitro
. Fe-PA-HCP has a higher relative bioavailability versus FePP, especially when bouillon is served with an inhibitory food matrix.
Publisher
Nature Publishing Group UK,Nature Publishing Group
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