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Telomerase gene therapy: a novel approach to combat aging
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Journal Article
Telomerase gene therapy: a novel approach to combat aging
2012
Overview
Partial or complete loss of telomerase function dramatically accelerates aging in mice and promotes aging associated disorders in humans. [...]the presence of active telomerase in stem cells, and potentially in other cells, is vital for longevity and good health. [...]animals display improved healthspan and extended lifespan. In support of this, Bernardes de Jesus et al demonstrate that a mutant form of mTERT incapable of extending telomeres was unable to provide any of the rejuvenating and lifespan extending effects of catalytically active TERT. [...]these studies also provide additional evidence that telomere erosion contributes to the functional decline of tissues in the mouse.
