Asset Details
Do you wish to reserve the book?
High Mobility Group Box Protein 1 (HMGB1): The Prototypical Endogenous Danger Molecule
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
High Mobility Group Box Protein 1 (HMGB1): The Prototypical Endogenous Danger Molecule
Do you wish to request the book?
High Mobility Group Box Protein 1 (HMGB1): The Prototypical Endogenous Danger Molecule
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
High Mobility Group Box Protein 1 (HMGB1): The Prototypical Endogenous Danger Molecule
2015
Overview
High mobility group box protein 1 (HMGB1) is an evolutionary ancient nuclear protein that exerts divergent biological tasks inside and outside of cells. The functions of HMGB1 depend on location, binding partners and redox states of the molecule. In the nucleus, HMGB1 organizes DNA and nucleosomes and regulates gene transcription. Upon cell activation or injury, nuclear HMGB1 can translocate to the cytoplasm, where it is involved in inflammasome activation and pyroptosis, as well as regulation of the autophagy/apoptosis balance. When actively secreted or passively released into the extracellular milieu, HMGB1 has cytokine, chemokine, neuroimmune and metabolic activities. Thus, HMGB1 plays multiple roles in the pathogenesis of inflammatory diseases and mediates immune responses that range from inflammation and bacterial killing to tissue repair. HMGB1 has been associated with divergent clinical conditions such as sepsis, rheumatoid arthritis and atherosclerosis. HMGB1 initiates and perpetuates immune responses during infectious and sterile inflammation, as the archetypical alarmin and damage-associated molecular pattern (DAMP) molecule. We here describe advances in the understanding of HMGB1 biology with focus on recent findings of its mission as a DAMP in danger sensing and as a therapeutic target in inflammatory diseases.
Publisher
BioMed Central,Springer Nature B.V,The Feinstein Institute Press
Subject
/ Arthritis, Rheumatoid - genetics
/ Arthritis, Rheumatoid - immunology
/ Arthritis, Rheumatoid - pathology
/ Atherosclerosis - immunology
/ Biomedical and Life Sciences
/ Chemokine CXCL12 - immunology
/ Humans
/ Ischemia
/ Proteins
/ Receptor for Advanced Glycation End Products - genetics
/ Receptor for Advanced Glycation End Products - immunology
/ Receptors, CXCR4 - immunology
/ Sepsis
/ Toll-Like Receptor 4 - genetics
