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Transition between fermentation and respiration determines history-dependent behavior in fluctuating carbon sources
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Journal Article
Transition between fermentation and respiration determines history-dependent behavior in fluctuating carbon sources
2018
Overview
Cells constantly adapt to environmental fluctuations. These physiological changes require time and therefore cause a lag phase during which the cells do not function optimally. Interestingly, past exposure to an environmental condition can shorten the time needed to adapt when the condition re-occurs, even in daughter cells that never directly encountered the initial condition. Here, we use the molecular toolbox of Saccharomyces cerevisiae to systematically unravel the molecular mechanism underlying such history-dependent behavior in transitions between glucose and maltose. In contrast to previous hypotheses, the behavior does not depend on persistence of proteins involved in metabolism of a specific sugar. Instead, presence of glucose induces a gradual decline in the cells’ ability to activate respiration, which is needed to metabolize alternative carbon sources. These results reveal how trans-generational transitions in central carbon metabolism generate history-dependent behavior in yeast, and provide a mechanistic framework for similar phenomena in other cell types.
Publisher
eLife Sciences Publications Ltd,eLife Sciences Publications, Ltd
Subject
/ Biology
/ Carbohydrates - pharmacology
/ Computational and Systems Biology
/ Gene Expression Regulation, Fungal - drug effects
/ Gene Regulatory Networks - drug effects
/ Genes
/ Genomes
/ Genomics
/ Maltose
/ Microbiology and Infectious Disease
/ Oxygen Consumption - drug effects
/ Proteins
/ Saccharomyces cerevisiae - drug effects
/ Saccharomyces cerevisiae - genetics
/ Saccharomyces cerevisiae - growth & development
/ Saccharomyces cerevisiae - metabolism
/ Saccharomyces cerevisiae Proteins - genetics
/ Saccharomyces cerevisiae Proteins - metabolism
/ Sugar
