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Serological evidence of zoonotic filovirus exposure among bushmeat hunters in Guinea
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Serological evidence of zoonotic filovirus exposure among bushmeat hunters in Guinea
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Journal Article
Serological evidence of zoonotic filovirus exposure among bushmeat hunters in Guinea
2024
Overview
Human Ebola virus (EBOV) outbreaks caused by persistent EBOV infection raises questions on the role of zoonotic spillover in filovirus epidemiology. To characterise filovirus zoonotic exposure, we collected cross-sectional serum samples from bushmeat hunters (
n
= 498) in Macenta Prefecture Guinea, adjacent to the index site of the 2013 EBOV-Makona spillover event. We identified distinct immune signatures (20/498, 4.0%) to multiple EBOV antigens (GP, NP, VP40) using stepwise ELISA and Western blot analysis and, live EBOV neutralisation (5/20; 25%). Using comparative serological data from PCR-confirmed survivors of the 2013-2016 EBOV outbreak, we demonstrated that most signatures (15/20) were not plausibly explained by prior EBOV-Makona exposure. Subsequent data-driven modelling of EBOV immunological outcomes to remote-sensing environmental data also revealed consistent associations with intact closed canopy forest. Together our findings suggest exposure to other closely related filoviruses prior to the 2013-2016 West Africa epidemic and highlight future surveillance priorities.
In a serological analysis, Bore et al. utilise serum samples, collected from a cohort of individuals associated with bushmeat hunting and butchering, in the forested region of Guinea, a region close to the epicentre of the 2013–2016 West Africa Ebola virus disease epidemic.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 82/1
/ Adult
/ Aged
/ Animals
/ Antibodies, Viral - immunology
/ Antigens
/ Antigens, Viral - immunology
/ Ebolavirus - isolation & purification
/ Enzyme-Linked Immunosorbent Assay
/ Exposure
/ Female
/ Hemorrhagic Fever, Ebola - blood
/ Hemorrhagic Fever, Ebola - epidemiology
/ Hemorrhagic Fever, Ebola - immunology
/ Hemorrhagic Fever, Ebola - transmission
/ Hemorrhagic Fever, Ebola - virology
/ Humanities and Social Sciences
/ Humans
/ Male
/ Science
/ Serology
/ Viral Zoonoses - epidemiology
/ Viral Zoonoses - transmission
/ Zoonoses
