Asset Details
Do you wish to reserve the book?
PilY1 and minor pilins form a complex priming the type IVa pilus in Myxococcus xanthus
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
PilY1 and minor pilins form a complex priming the type IVa pilus in Myxococcus xanthus
Do you wish to request the book?
PilY1 and minor pilins form a complex priming the type IVa pilus in Myxococcus xanthus
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
PilY1 and minor pilins form a complex priming the type IVa pilus in Myxococcus xanthus
2020
Overview
Type IVa pili are ubiquitous and versatile bacterial cell surface filaments that undergo cycles of extension, adhesion and retraction powered by the cell-envelope spanning type IVa pilus machine (T4aPM). The overall architecture of the T4aPM and the location of 10 conserved core proteins within this architecture have been elucidated. Here, using genetics, cell biology, proteomics and cryo-electron tomography, we demonstrate that the PilY1 protein and four minor pilins, which are widely conserved in T4aP systems, are essential for pilus extension in
Myxococcus xanthus
and form a complex that is an integral part of the T4aPM. Moreover, these proteins are part of the extended pilus. Our data support a model whereby the PilY1/minor pilin complex functions as a priming complex in T4aPM for pilus extension, a tip complex in the extended pilus for adhesion, and a cork for terminating retraction to maintain a priming complex for the next round of extension.
Type IVa pili are bacterial surface filaments that undergo extension and retraction powered by a protein machine that spans the cell envelope. Here, Treuner-Lange et al. show that a complex formed by PilY1 and minor pilins is an integral part of this machine and is necessary for pilus extension, adhesion and retraction termination.
Publisher
Nature Publishing Group UK,Nature Portfolio
Subject
/ 101/58
/ 14
/ 14/28
/ 14/35
/ 82/111
/ 82/58
/ 82/83
/ 96/63
/ Bacterial Adhesion - physiology
/ Electron Microscope Tomography
/ Fimbriae Proteins - genetics
/ Fimbriae Proteins - metabolism
/ Fimbriae, Bacterial - genetics
/ Fimbriae, Bacterial - metabolism
/ Humanities and Social Sciences
/ Mutation
/ Myxococcus xanthus - cytology
/ Myxococcus xanthus - physiology
/ Science
