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Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model
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Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model
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Journal Article
Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model
2020
Overview
Reactive astrocytes have been implicated in the pathogenesis of neurodegenerative diseases, including a non-cell autonomous effect on motor neuron survival in ALS. We previously defined a mechanism by which microglia release three factors, IL-1α, TNFα, and C1q, to induce neurotoxic astrocytes. Here we report that knocking out these three factors markedly extends survival in the
SOD1
G93A
ALS mouse model, providing evidence for gliosis as a potential ALS therapeutic target.
Astrocyte activation may contribute to neurodegenerative disease. Here the authors show that the combined knockout of three factors known to promote astrogliosis, IL-1α, TNFα and C1qa, leads to improved survival in the
SOD1
G93A
mouse model of ALS.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
