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Biocompatibility between Silicon or Silicon Carbide surface and Neural Stem Cells
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Journal Article
Biocompatibility between Silicon or Silicon Carbide surface and Neural Stem Cells
2019
Overview
Silicon has been widely used as a material for microelectronic for more than 60 years, attracting considerable scientific interest as a promising tool for the manufacture of implantable medical devices in the context of neurodegenerative diseases. However, the use of such material involves responsibilities due to its toxicity, and researchers are pushing towards the generation of new classes of composite semiconductors, including the Silicon Carbide (3C-SiC). In the present work, we tested the biocompatibility of Silicon and 3C-SiC using an
in vitro
model of human neuronal stem cells derived from dental pulp (DP-NSCs) and mouse Olfactory Ensheathing Cells (OECs), a particular glial cell type showing stem cell characteristics. Specifically, we investigated the effects of 3C-SiC on neural cell morphology, viability and mitochondrial membrane potential. Data showed that both DP-NSCs and OECs, cultured on 3C-SiC, did not undergo consistent oxidative stress events and did not exhibit morphological modifications or adverse reactions in mitochondrial membrane potential. Our findings highlight the possibility to use Neural Stem Cells plated on 3C-SiC substrate as clinical tool for lesioned neural areas, paving the way for future perspectives in novel cell therapies for neuro-degenerated patients.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/100
/ 13/51
/ 14
/ 14/1
/ 14/34
/ 631/378
/ Animals
/ Biocompatible Materials - chemistry
/ Biocompatible Materials - pharmacology
/ Biocompatible Materials - therapeutic use
/ Carbon Compounds, Inorganic - chemistry
/ Carbon Compounds, Inorganic - pharmacology
/ Cell Survival - drug effects
/ Cytology
/ Dental restorative materials
/ Humanities and Social Sciences
/ Humans
/ Mice
/ Neural Stem Cells - drug effects
/ Science
/ Silicon
/ Silicon Compounds - chemistry
/ Silicon Compounds - pharmacology
/ Toxicity
