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A Trial of a 7-Valent Pneumococcal Conjugate Vaccine in HIV-Infected Adults
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A Trial of a 7-Valent Pneumococcal Conjugate Vaccine in HIV-Infected Adults
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Journal Article
A Trial of a 7-Valent Pneumococcal Conjugate Vaccine in HIV-Infected Adults
2010
Overview
Pneumococcal infection is an important cause of death and complications in adults with human immunodeficiency virus (HIV) infection, particularly in Africa. In this placebo-controlled, randomized trial involving 496 predominantly HIV-infected Malawian adults who had recently had an invasive pneumococcal infection, the 7-valent conjugated pneumococcal vaccine was found to have 74% efficacy in preventing subsequent invasive pneumococcal infection with a vaccine-associated serotype.
In predominantly HIV-infected Malawian adults who had recently had an invasive pneumococcal infection, the 7-valent conjugated pneumococcal vaccine was found to have 74% efficacy in preventing subsequent invasive pneumococcal infection.
Streptococcus pneumoniae
is a leading cause of death and complications in adults with human immunodeficiency virus (HIV) infection, particularly in sub-Saharan Africa.
1
,
2
The risk of invasive pneumococcal disease is 30 to 100 times as high in patients with HIV infection as in age-matched controls without such infection.
3
,
4
Recurrent invasive pneumococcal disease is common, with up to 25% of patients having an additional episode, predominantly reinfection, in the subsequent 12 months.
1
,
5
Even among patients who have access to timely and effective care, the case fatality rate with invasive pneumococcal disease is at least 8%
6
and rises to 50% . . .
Publisher
Massachusetts Medical Society
Subject
/ Adult
/ Aged
/ AIDS-Related Opportunistic Infections - epidemiology
/ AIDS-Related Opportunistic Infections - prevention & control
/ Biological and medical sciences
/ Female
/ Heptavalent Pneumococcal Conjugate Vaccine
/ HIV
/ HIV Infections - complications
/ Human immunodeficiency virus
/ Humans
/ Male
/ Pneumococcal Vaccines - adverse effects
/ Pneumonia, Pneumococcal - epidemiology
/ Pneumonia, Pneumococcal - etiology
/ Pneumonia, Pneumococcal - prevention & control
/ Staphylococcal infections, streptococcal infections, pneumococcal infections
/ Streptococcus pneumoniae - classification
/ Vaccines
