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Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body’s defence against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects
by
Busch, Regina
, Bothe, Gordana
, Gruenwald, Joerg
, Auinger, Annegret
, Riede, Linda
in
Adolescent
/ Adult
/ Aged
/ beta-glucans
/ beta-Glucans - pharmacology
/ Chemistry
/ Chemistry and Materials Science
/ clinical trials
/ common cold
/ Common Cold - drug therapy
/ Common Cold - prevention & control
/ Dietary Supplements
/ Double-Blind Method
/ drug therapy
/ Female
/ Healthy Volunteers
/ Humans
/ Male
/ Middle Aged
/ Nutrition
/ Original Contribution
/ pathogens
/ pharmacology
/ physicians
/ prevention & control
/ Saccharomyces cerevisiae
/ Saccharomyces cerevisiae - chemistry
/ sleep
/ Treatment Outcome
/ yeasts
/ Young Adult
2013
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Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body’s defence against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects
by
Busch, Regina
, Bothe, Gordana
, Gruenwald, Joerg
, Auinger, Annegret
, Riede, Linda
in
Adolescent
/ Adult
/ Aged
/ beta-glucans
/ beta-Glucans - pharmacology
/ Chemistry
/ Chemistry and Materials Science
/ clinical trials
/ common cold
/ Common Cold - drug therapy
/ Common Cold - prevention & control
/ Dietary Supplements
/ Double-Blind Method
/ drug therapy
/ Female
/ Healthy Volunteers
/ Humans
/ Male
/ Middle Aged
/ Nutrition
/ Original Contribution
/ pathogens
/ pharmacology
/ physicians
/ prevention & control
/ Saccharomyces cerevisiae
/ Saccharomyces cerevisiae - chemistry
/ sleep
/ Treatment Outcome
/ yeasts
/ Young Adult
2013
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Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body’s defence against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects
by
Busch, Regina
, Bothe, Gordana
, Gruenwald, Joerg
, Auinger, Annegret
, Riede, Linda
in
Adolescent
/ Adult
/ Aged
/ beta-glucans
/ beta-Glucans - pharmacology
/ Chemistry
/ Chemistry and Materials Science
/ clinical trials
/ common cold
/ Common Cold - drug therapy
/ Common Cold - prevention & control
/ Dietary Supplements
/ Double-Blind Method
/ drug therapy
/ Female
/ Healthy Volunteers
/ Humans
/ Male
/ Middle Aged
/ Nutrition
/ Original Contribution
/ pathogens
/ pharmacology
/ physicians
/ prevention & control
/ Saccharomyces cerevisiae
/ Saccharomyces cerevisiae - chemistry
/ sleep
/ Treatment Outcome
/ yeasts
/ Young Adult
2013
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Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body’s defence against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects
Journal Article
Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body’s defence against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects
2013
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Overview
PURPOSE: The effect of brewers’ yeast (1,3)-(1,6)-beta-D-glucan consumption on the number of common cold episodes in healthy subject was investigated. METHODS: In a placebo-controlled, double-blind, randomized, multicentric clinical trial, 162 healthy participants with recurring infections received 900 mg of either placebo (n = 81) or an insoluble yeast (1,3)-(1,6)-beta-D-glucan preparation (n = 81) per day over a course of 16 weeks. Subjects were instructed to document each occurring common cold episode in a diary and to rate ten predefined infection symptoms during an infections period, resulting in a symptom score. The subjects were examined by the investigator during the episode visit on the 5th day of each cold episode. RESULTS: In the per protocol population, supplementation with insoluble yeast (1,3)-(1,6)-beta-glucan reduced the number of symptomatic common cold infections by 25 % as compared to placebo (p = 0.041). The mean symptom score was 15 % lower in the beta-glucan as opposed to the placebo group (p = 0.125). Beta-glucan significantly reduced sleep difficulties caused by cold episode as compared to placebo (p = 0.028). Efficacy of yeast beta-glucan was rated better than the placebo both by physicians (p = 0.004) participants (p = 0.012). CONCLUSION: The present study demonstrated that yeast beta-glucan preparation increased the body’s potential to defend against invading pathogens.
Publisher
Springer-Verlag,Springer Berlin Heidelberg,Springer Nature B.V
Subject
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