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Immunobridging Trials: An Important Tool to Protect Vulnerable and Immunocompromised Patients Against Evolving Pathogens

by Lee, Lennard Y. W. , Lam, Jie Min , Pagliuca, Antonio , Ying, Yuxin , Gill, John , Cruz, Pedro , Samuels, Ffion , Bytyci, Jola , Hoerger, Michael , Abdalla, Jehad , Bell, Samira , Raffi, Francois , Brosh-Nissimov, Tal , Haidar, Ghady , Maor, Yasmin , Segev, Dorry

in Care and treatment / Clinical trials / COVID-19 / COVID-19 vaccines / Disease prevention / Drug dosages / Effectiveness / Epidemics / Human health and pathology / Human papillomavirus / Immunity (Disease) / immunobridging / immunocompromise / Immunocompromised host / Immunocompromised hosts / Immunology / Infections / Infectious diseases / Influenza / Kidney diseases / Life Sciences / Monoclonal antibodies / Opinion / Pathogens / Patients / Product development / Severe acute respiratory syndrome coronavirus 2 / Vaccines

2025

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Immunobridging Trials: An Important Tool to Protect Vulnerable and Immunocompromised Patients Against Evolving Pathogens

2025

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Immunobridging Trials: An Important Tool to Protect Vulnerable and Immunocompromised Patients Against Evolving Pathogens

2025

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Journal Article

Immunobridging Trials: An Important Tool to Protect Vulnerable and Immunocompromised Patients Against Evolving Pathogens

Lee, Lennard Y. W.,

Lam, Jie Min,

Pagliuca, Antonio,

Ying, Yuxin,

Gill, John,

Cruz, Pedro,

Samuels, Ffion,

Bytyci, Jola,

Hoerger, Michael,

Abdalla, Jehad,

Bell, Samira,

Raffi, Francois,

Brosh-Nissimov, Tal,

Haidar, Ghady,

Maor, Yasmin,

Segev, Dorry

2025

Overview

Safeguarding patients from emerging infectious diseases demands strategies that prioritise patient well-being and protection. Immunobridging is an established trial methodology which has been increasingly employed to ensure patient protection and provide clinicians with swift access to vaccines. It uses immunological markers to infer the effectiveness of a new drug through a surrogate measure of efficacy. Recently, this method has also been employed to authorise novel drugs, such as COVID-19 vaccines, and this article explores the concepts behind immunobridging trials, their advantages, issues, and significance in the context of COVID-19 and other infectious diseases. Our goal is to improve awareness among clinicians, patient groups, regulators, and health leaders of the opportunities and issues of immunobridging, so that fewer patients are left without protection from infectious diseases, particularly from major pathogens that may emerge.

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MDPI AG,MDPI

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