Journal Article

Spatiotemporal evolution of online interest in assisted reproductive technology: a two-decade global analysis through google trends

Gao, Yuzhou, Ji, Dongmei, Wan, Xingyu, Yang, Yang, He, Haoyu, Zhang, Ning

2025

Overview

Background Online interest could serve as critical sentinel indicators for monitoring assisted reproductive technology (ART) demands, detecting regions with access inequities, and identifying shortcomings in policy frameworks; however, global online interest of ART has not been assessed. The study aims to investigate the spatiotemporal evolution of online interest in ART globally. Methods The study follows retrospective observational design. Data were derived from Google Trends and Relative Search Volume (RSV) data across 230 countries and regions were collected. After quality control, data from 59, 76, 69, and 61 countries and regions were included for different search terms (“Assisted reproductive technology,” “In vitro fertilization,” “Intracytoplasmic sperm injection,” and “Preimplantation genetic diagnosis,” respectively). Weekly percentage changes (WPCs) and annual percentage changes (APCs) were used to quantify the temporal variations in online interest. Results Globally, public online interest in ART demonstrated a distinct seasonal fluctuation, peaking during months 3–5 and 9–11, while declining in months 6–8 and 12 − 2. The global online interest showed a significant downward trend (APC = -11.22%, 95% Confidence Interval [CI]: -18.44 to -8.61) from 2004 to 2011, followed by a gradual increase from 2011 to 2016 (APC = 1.76%, 95% CI: -7.64 to 11.99). Interest then rapidly increased from 2016 to 2019 (APC = 27.24%, 95% CI: 12.48 to 35.20), before continuing to decline after 2020 (APC = -6.54%, 95% CI: -12.52 to -3.05) with predictions indicating further decreases by 2030. Overall, Europe exhibited relatively higher online interest, while Africa and Oceania showed lower levels. In Europe, France (RSV = 76), Italy (RSV = 66), and Spain (RSV = 32) had notable interest in ART. Whereas, in Oceania and Africa, Australia (RSV = 8), New Zealand (RSV = 6), Tunisia (RSV = 16), Algeria (RSV = 16), and Nigeria (RSV = 10) showed lower levels of interest. Israel, Réunion (France), and France ranked as the top three countries or regions with the highest online interest in ART worldwide. Conclusions Global online interest in ART shows significant variation across countries and regions, with a decline after 2020. To address these trends, ART resources and services should be allocated effectively based on seasonal and regional demand. Government action is needed to raise social awareness and improve the accessibility and utilization of ART.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Analysis / Assisted reproductive technology / Biostatistics / Environmental Health / Epidemiology / Genetic screening / Google trends / Health aspects / Humans / In vitro fertilization / Infertility / Infodemiology / Information seeking behavior / Internet / Internet - statistics & numerical data / Medicine / Medicine & Public Health / Prevention / Public Health / Public opinion / Quality control / Rankings / Reproductive health / Reproductive Techniques, Assisted - statistics & numerical data / Reproductive Techniques, Assisted - trends / Reproductive technologies / Reproductive technology / Retrospective Studies / Risk factors / RSV / Search Engine - statistics & numerical data / Search Engine - trends / Search engines / Search strategies / Seasonal variations / Spatio-Temporal Analysis / Spatiotemporal analysis / Sperm / Technology / Temporal variations / Time series / Time trends (Statistics) / Trends / Vaccine