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Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-18Ffluoro-D-glucose positron emission and computed tomography
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Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-18Ffluoro-D-glucose positron emission and computed tomography
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Journal Article
Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-18Ffluoro-D-glucose positron emission and computed tomography
2016
Overview
By using combined positron emission and computed tomography (PET–CT), Esmail
et al.
show that some patients with latent tuberculosis have signs of subclinical, active disease in the lungs and a greater likelihood of progression, suggesting a spectrum of disease rather than discrete latent and active disease states.
Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-therapy-naive, HIV-1-infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were substantially more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers that are predictive of progression.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 82/51
/ 82/80
/ 9/74
/ Adult
/ Adults
/ Analysis
/ Coinfection - diagnostic imaging
/ Female
/ Glucose
/ HIV
/ HIV Infections - complications
/ Human immunodeficiency virus
/ Humans
/ Interferon-gamma Release Tests
/ Latent Tuberculosis - complications
/ Latent Tuberculosis - diagnostic imaging
/ Male
/ Mycobacterium tuberculosis - isolation & purification
/ Positron Emission Tomography Computed Tomography
/ Tuberculosis - complications
/ Tuberculosis - diagnostic imaging
