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Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
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Journal Article
Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
2019
Overview
Accumulating evidence illustrates a fundamental role for mitochondria in lung alveolar type 2 epithelial cell (AEC2) dysfunction in the pathogenesis of idiopathic pulmonary fibrosis. However, the role of mitochondrial fusion in AEC2 function and lung fibrosis development remains unknown. Here we report that the absence of the mitochondrial fusion proteins mitofusin1 (MFN1) and mitofusin2 (MFN2) in murine AEC2 cells leads to morbidity and mortality associated with spontaneous lung fibrosis. We uncover a crucial role for MFN1 and MFN2 in the production of surfactant lipids with MFN1 and MFN2 regulating the synthesis of phospholipids and cholesterol in AEC2 cells. Loss of MFN1, MFN2 or inhibiting lipid synthesis via fatty acid synthase deficiency in AEC2 cells exacerbates bleomycin-induced lung fibrosis. We propose a tenet that mitochondrial fusion and lipid metabolism are tightly linked to regulate AEC2 cell injury and subsequent fibrotic remodeling in the lung.
Mitochondria of alveolar type 2 epithelial cells (AEC2) in the lung have been suggested to play a role in the development of idiopathic pulmonary fibrosis (IPF). Here the authors show that loss of mitofusin1 and mitofusin2 in murine AEC2 cells leads to the development of lung fibrosis through the regulation of surfactant lipids.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/31
/ 13/51
/ 14/19
/ 14/28
/ 38/22
/ 38/90
/ 38/91
/ 64/60
/ 82/80
/ Alveolar Epithelial Cells - drug effects
/ Alveolar Epithelial Cells - metabolism
/ Alveolar Epithelial Cells - pathology
/ Alveoli
/ Animals
/ Antibiotics, Antineoplastic - toxicity
/ Fibrosis
/ GTP Phosphohydrolases - genetics
/ GTP Phosphohydrolases - metabolism
/ Humanities and Social Sciences
/ Idiopathic Pulmonary Fibrosis - chemically induced
/ Idiopathic Pulmonary Fibrosis - genetics
/ Idiopathic Pulmonary Fibrosis - metabolism
/ Lipids
/ Mitochondrial Dynamics - drug effects
/ Mitochondrial Dynamics - genetics
/ Phospholipids - biosynthesis
/ Science
