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CHML promotes liver cancer metastasis by facilitating Rab14 recycle
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Journal Article
CHML promotes liver cancer metastasis by facilitating Rab14 recycle
2019
Overview
Metastasis-associated recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC), however, the underlying mechanisms remain largely elusive. In this study, we report that expression of choroideremia-like (CHML) is increased in HCC, associated with poor survival, early recurrence and more satellite nodules in HCC patients. CHML promotes migration, invasion and metastasis of HCC cells, in a Rab14-dependent manner. Mechanism study reveals that CHML facilitates constant recycling of Rab14 by escorting Rab14 to the membrane. Furthermore, we identify several metastasis regulators as cargoes carried by Rab14-positive vesicles, including Mucin13 and CD44, which may contribute to metastasis-promoting effects of CHML. Altogether, our data establish CHML as a potential promoter of HCC metastasis, and the CHML-Rab14 axis may be a promising therapeutic target for HCC.
Metastasis-associated recurrence is a major cause of poor prognosis in hepatocellular carcinoma. Here, the authors show that expression of choroideremia-like (CHML) is elevated and associates with poor prognosis in hepatocellular carcinoma, and mechanistically CHML promotes metastasis in a Rab14-dependent manner.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
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/ 14
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/ 14/5
/ 38
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/ 49
/ 631/67
/ 82/80
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/ 96
/ Adaptor Proteins, Signal Transducing - genetics
/ Adaptor Proteins, Signal Transducing - metabolism
/ Animals
/ Carcinoma, Hepatocellular - genetics
/ Carcinoma, Hepatocellular - metabolism
/ Carcinoma, Hepatocellular - secondary
/ Humanities and Social Sciences
/ Humans
/ Hyaluronan Receptors - metabolism
/ Liver Neoplasms - metabolism
/ Mice
/ Neoplasm Recurrence, Local - genetics
/ Neoplasm Recurrence, Local - metabolism
/ Neoplasms, Multiple Primary - metabolism
/ Neoplasms, Multiple Primary - pathology
/ Nodules
/ rab GTP-Binding Proteins - metabolism
/ Science
